Recent Progress of Stem Cell Therapy in Cancer Treatment: Molecular Mechanisms and Potential Applications
| Autor: | Dang-Khoa Tran, Nguyen Le Bao Tien, Jee-Heon Jeong, Dinh-Toi Chu, Dang Tien Truong, Vo Van Thanh, Pham Gia Anh, Tiep Tien Nguyen, Thien Chu Dinh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
Review Cancer recurrence Regenerative medicine Cancer Vaccines cancer treatment Immune system Risk Factors stem cells Neoplasms medicine Humans lcsh:QH301-705.5 Clinical Trials as Topic mechanisms business.industry Cancer General Medicine Stem-cell therapy medicine.disease Cancer treatment Targeted drug delivery lcsh:Biology (General) Cancer research Stem cell business application Stem Cell Transplantation |
| Zdroj: | Cells Cells, Vol 9, Iss 3, p 563 (2020) |
| ISSN: | 2073-4409 |
| Popis: | The insufficient and unspecific target of traditional therapeutic approaches in cancer treatment often leads to therapy resistance and cancer recurrence. Over the past decades, accumulating discoveries about stem cell biology have provided new potential approaches to cure cancer patients. Stem cells possess unique biological actions, including self-renewal, directional migration, differentiation, and modulatory effects on other cells, which can be utilized as regenerative medicine, therapeutic carriers, drug targeting, and generation of immune cells. In this review, we emphasize the mechanisms underlying the use of various types of stem cells in cancer treatment. In addition, we summarize recent progress in the clinical applications of stem cells, as well as common risks of this therapy. We finally give general directions for future studies, aiming to improve overall outcomes in the fight against cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |