Aluminium toxicosis: a review of toxic actions and effects
| Autor: | Ephraim Igwenagu, Nanacha Afifi Igbokwe, Ikechukwu Onyebuchi Igbokwe |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
toxicosis
Health Toxicology and Mutagenesis Toxic Actions Review Article 010501 environmental sciences Toxicology Desquamative interstitial pneumonia medicine.disease_cause 01 natural sciences 03 medical and health sciences intoxication Fibrosis RA1190-1270 medicine 030304 developmental biology 0105 earth and related environmental sciences Pharmacology 0303 health sciences Osteomalacia business.industry aluminium Macrophagic myofasciitis toxicity medicine.disease Toxicology. Poisons Immunology Pancreatitis pathology Pulmonary alveolar proteinosis business Oxidative stress |
| Zdroj: | Interdisciplinary Toxicology Interdisciplinary Toxicology, Vol 12, Iss 2, Pp 45-70 (2019) |
| ISSN: | 1337-9569 |
| DOI: | 10.2478/intox-2019-0007 |
| Popis: | Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn’s disease, inflammatory bowel diseases, anemia, Alzheimer’s disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus. The review provides a broad overview of Al toxicosis as a background for sustained investigations of the toxicology of Al compounds of public health importance. |
| Databáze: | OpenAIRE |
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