Cardiac secretion of atrial natriuretic factor with exercise in chronic congestive heart failure patients
| Autor: | Robert J. Cody, S. H. Kubo, J. H. Laragh, S. A. Atlas |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Mean arterial pressure Cardiac output Ergometry Physiology Physical exercise Atrial natriuretic peptide Physiology (medical) Internal medicine Heart rate otorhinolaryngologic diseases medicine Humans Pulmonary Wedge Pressure Pulmonary wedge pressure Exercise Aged Heart Failure Neurotransmitter Agents Pulmonary Gas Exchange business.industry Myocardium Hemodynamics Middle Aged musculoskeletal system medicine.disease Endocrinology medicine.anatomical_structure Heart failure Chronic Disease cardiovascular system Cardiology Vascular resistance Female business Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Applied Physiology. 73:1637-1643 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1992.73.4.1637 |
| Popis: | We have previously reported a fivefold increase of plasma atrial natriuretic factor (ANF) in patients with congestive heart failure (CHF) compared with normal subjects. However, given the marked increase of ANF under basal conditions, the extent to which ANF secretion can further increase under physiological stress is not been clarified in CHF. We therefore evaluated ANF secretion during ergometric exercise in 11 patients with CHF, with peripheral venous ANF samples obtained at rest and peak exercise. In seven patients, simultaneous peripheral venous and right ventricular ANF samples were obtained to estimate myocardial ANF secretion. Hemodynamic characteristics of exercise included a significant increase of heart rate, mean arterial pressure, and cardiac output (all P < 0.01); reduction of systemic vascular resistance (P < 0.001); and increase of right atrial and pulmonary wedge pressures (P < 0.001). ANF was abnormally elevated at baseline (108 +/- 58 fmol/ml) yet increased further to 183 +/- 86 fmol/ml with exercise (P < 0.003). A step-up of right ventricular ANF, particularly during exercise, was consistent with active myocardial secretion, despite elevated baseline ANF levels. |
| Databáze: | OpenAIRE |
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