| Popis: |
The cardiomyocytes of zebrafish can regenerate in case of necrosis. Several studies have shown that the Bone morphogenetic signaling pathway (BMP signaling) is involved in the process of zebrafish heart regeneration. To identify candidate mediators of BMP signaling action on alleviation of genomic stress, the heat shock protein-mediated BMP transgenic zebrafish were used to achieve BMP signaling upregulation after cryoinjury and then the qPCR technology was used to test the expression of related genes during heart regeneration. Interestingly, my results show that cyclin dependent kinase 1 (cdk1) is upregulated upon overexpression of BMP signaling in regenerating hearts in a regeneration specific manner. I found that cdk1 could be a downstream target of BMP signaling, and there is difference gene expression between zebrafish and human cells. Further research on the molecular control of cardiac regeneration can use our findings as a starting point. |
