Hemodynamic and respiratory effects of dezocine, ciramadol, and morphine
Autor: | Bernard F. Schreiner, Robert L Rothbard, Paul N. Yu |
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Rok vydání: | 1985 |
Předmět: |
Adult
Male Benzylamines Cardiac Catheterization Mean arterial pressure medicine.medical_specialty Tetrahydronaphthalenes Cardiac index Hemodynamics Random Allocation Double-Blind Method Internal medicine Humans Medicine Ciramadol Pharmacology (medical) Amines Pulmonary wedge pressure Aged Pharmacology Analysis of Variance Morphine business.industry Respiration Cycloparaffins Stroke volume Middle Aged Bridged Bicyclo Compounds Heterocyclic Dezocine medicine.anatomical_structure Anesthesia Cardiology Vascular resistance Drug Evaluation business medicine.drug |
Zdroj: | Clinical Pharmacology and Therapeutics. 38:84-88 |
ISSN: | 1532-6535 0009-9236 |
DOI: | 10.1038/clpt.1985.139 |
Popis: | The hemodynamic and respiratory effects of dezocine and ciramadol, two agonist-antagonist analgesics, were compared with those of morphine in 30 patients undergoing diagnostic cardiac catheterization. Each subject received a single intravenous dose of dezocine (0.125 mg/kg), ciramadol (0.6 mg/kg), or morphine (0.125 mg/kg) in a double-blind fashion. Hemodynamic and respiratory parameters were measured at baseline and 5, 10, and 20 minutes after dosing. Dezocine increased the cardiac index (CI; 2.67 to 2.92 L/min/m2), stroke volume index (SVI; 43.6 to 47.6 ml/beat/m2), left ventricular stroke work index (LVSWI; 57.4 to 64.7 gm-m/m2), and pulmonary vascular resistance (PVR; 105.6 to 154.0 dynes X sec/cm5). Ciramadol increased the CI (2.78 to 3.22 L/min/m2), SVI (40.9 to 48.2 ml/beat/m2), LVSWI (51.1 to 57.9 gm-m/m2), and mean pulmonary arterial pressure (PA; 14.7 to 18.9 mm Hg). Morphine had no effect on CI, SVI, LVSWI, PA, or PVR, but it significantly lowered systolic and diastolic blood pressures. There were no appreciable changes in heart rate, left ventricular end-diastolic pressure, mean arterial pressure, or mean pulmonary capillary wedge pressure after any of the drugs. All three drugs significantly decreased systemic vascular resistance. There were no clinically significant changes in respiratory parameters. We conclude that dezocine, ciramadol, and morphine have no clinically important adverse effects on cardiac performance. |
Databáze: | OpenAIRE |
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