Quantitative Gradient Echo MRI Identifies Dark Matter as a New Imaging Biomarker of Neurodegeneration that Precedes Tisssue Atrophy in Early Alzheimer's Disease
| Autor: | Anne M. Fagan, Andrew J. Aschenbrenner, Manu S. Goyal, Dmitriy A. Yablonskiy, Charles F. Hildebolt, Richard J. Perrin, Satya V.V.N. Kothapalli, Marcus E. Raichle, Tammie L.S. Benzinger, John C. Morris |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Pathology medicine.medical_specialty Imaging biomarker Hippocampus Atrophy In vivo Alzheimer Disease medicine Dementia Humans Cognitive Dysfunction Aged Aged 80 and over Amyloid beta-Peptides business.industry Echo-Planar Imaging General Neuroscience Neurodegeneration Brain General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology Case-Control Studies Disease Progression Linear Models Biomarker (medicine) Female Geriatrics and Gerontology Alzheimer's disease business Biomarkers |
| Zdroj: | Journal of Alzheimer's disease : JAD. 85(2) |
| ISSN: | 1875-8908 |
| Popis: | BackgroundCurrently, brain tissue atrophy serves as in vivo MRI biomarker of neurodegeneration in Alzheimer Disease (AD). However, postmortem histopathological studies show that neuronal loss in AD exceeds volumetric loss of tissue and that loss of memory in AD begins when neurons and synapses are lost. Therefore, in vivo detection of neuronal loss prior to detectable atrophy in MRI is essential for early AD diagnosis.ObjectiveTo apply a recently developed quantitative Gradient Recalled Echo (qGRE) MRI technique for in vivo evaluation of neuronal loss in human hippocampus.MethodsSeventy participants were recruited from the Knight Alzheimer Disease Research Center, representing three groups: Healthy controls [Clinical Dementia Rating® (CDR®)=0, amyloid β (Aβ)-negative), n=34]; Preclinical AD (CDR=0, Aβ-positive, n=19); and mild AD (CDR=0.5 or 1, Aβ-positive, n=17).ResultsIn hippocampal tissue, qGRE identified two types of regions: one, practically devoid of neurons, we designate as “Dark Matter”, the other, with relatively preserved neurons - “Viable Tissue”. Data showed a greater loss of neurons than defined by atrophy in the mild AD group compared with the healthy control group - neuronal loss ranged between 31% and 43% while volume loss ranged only between 10% and 19%. The concept of Dark Matter was confirmed with histopathological study of one participant who underwent in vivo qGRE 14 months prior to expiration.Conclusionin vivo qGRE method identifies neuronal loss that is associated with impaired AD-related cognition but is not recognized by MRI measurements of tissue atrophy, therefore providing new biomarkers for early AD detection. |
| Databáze: | OpenAIRE |
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