Chiral Luminescent Sensor Eu-BTB@d-Carnitine Applied in the Highly Effective Ratiometric Sensing of Curing Drugs and Biomarkers for Diabetes and Hypertension

Autor:	Yang Fan Shi, Yu Peng Jiang, Xing Ze Wang, Ping Ping Sun, Na Jia Zhu, Kuo Wang, Zi Qing Zhang, Yuan Yuan Liu, JianZhong Huo, Xin Rui Wang, Bin Ding
Rok vydání:	2022
Předmět:	Inorganic Chemistry Norepinephrine Europium Carnitine Hypertension Sitagliptin Phosphate Diabetes Mellitus Insulins Humans Physical and Theoretical Chemistry Biomarkers Clonidine Metal-Organic Frameworks
Zdroj:	Inorganic Chemistry. 61:15921-15935
ISSN:	1520-510X 0020-1669
DOI:	10.1021/acs.inorgchem.2c02126
Popis:	Chiral drugs are of great significance in drug development and life science because one pair of enantiomers has a different combination mode with target biological active sites, leading to a vast difference in physical activity. Metal-organic framework (MOF)-based chiral hybrid materials with specific chiral sites have excellent applications in the highly effective sensing of drug enantiomers. Sitagliptin and clonidine are effective curing drugs for controlling diabetes and hypertension, while insulin and norepinephrine are the biomarkers of these two diseases. Excessive use of sitagliptin and clonidine can cause side effects such as stomach pain, nausea, and headaches. Herein, through post-synthetic strategy, MOF-based chiral hybrid material
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a31102c66d62ce0e8ecc21af6d5ccf4 https://doi.org/10.1021/acs.inorgchem.2c02126 Zobrazit plný text záznamu