Model systems for the study of steroid-induced IOP elevation
| Autor: | John Danias, Rosana Gerometta, IIya Rybkin, Gabrielle Fridman, Oscar A. Candia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Intraocular pressure medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD genetic structures Cell Culture Techniques Glaucoma Aqueous humor Medicina Clínica Triamcinolone Acetonide Dexamethasone Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Organ Culture Techniques Trabecular Meshwork GLAUCOMA Ophthalmology Medicine Animals Humans Glucocorticoids Intraocular Pressure INTRAOCULAR PRESSURE business.industry STEROIDS Elevation medicine.disease Sensory Systems eye diseases MODEL Disease Models Animal 030104 developmental biology 030221 ophthalmology & optometry Ocular Hypertension Medicina Critica y de Emergencia business |
| Popis: | Steroid-induced IOP elevation affects a significant number of patients. It results from a decrease in outflow facility of the aqueous humor. To understand the pathophysiology of this condition a number of model systems have been created. These include ex-vivo cell and organ cultures as well as in-vivo animal models in organisms ranging from rodents to primates. These model systems can be used to investigate specific aspects of steroid-induced IOP elevation. This brief review summarizes the strengths and limitations of the various model systems and provides examples of where these systems have been successfully used to advance our understanding of steroid-induced IOP elevation. Fil: Rybkin, IIya. SUNY Downstate; Estados Unidos Fil: Gerometta, Rosana María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Comahue. Facultad de Medicina; Argentina. Icahn School of Medicine at Mount Sinai; Estados Unidos Fil: Fridman, Gabrielle. SUNY Downstate; Estados Unidos Fil: Candia, Oscar. Icahn School of Medicine at Mount Sinai; Estados Unidos Fil: Danias, John. SUNY Downstate; Estados Unidos |
| Databáze: | OpenAIRE |
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