Hispolon as an inhibitor of TGF-β-induced epithelial-mesenchymal transition in human epithelial cancer cells by co-regulation of TGF-β-Snail/Twist axis
| Autor: | Darong Hong, Jong Ho Kim, Bom Jung, Min Ju Park, Eun Hyang Jang, Nam-Jung Kim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Oncogene Hispolon Cell Cancer Cell migration Articles Biology medicine.disease Metastasis Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Oncology chemistry 030220 oncology & carcinogenesis Cancer cell medicine Epithelial–mesenchymal transition |
| Zdroj: | Oncology Letters. 14:4866-4872 |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2017.6789 |
| Popis: | Hispolon (HPL), isolated from Phellinus linteus, has been used to treat various types of pathology, including inflammation, gastroenteric disorders, lymphatic diseases and numerous cancer subtypes. HPL has previously been reported to demonstrate a significant therapeutic efficacy against various types of cancer cells, including melanoma, leukemia, hepatocarcinoma, bladder and gastric cancer cells. However, its potential role in the epithelial-mesenchymal transition (EMT) has not been demonstrated. The present study investigated the effects of HPL on the EMT. Transforming growth factor β (TGF-β) induced enhanced cell migration and invasion, EMT-associated phenotypic changes. In the present study, HPL recovered the reduction of E-cadherin expression level in TGF-β treated cancer cells, which was regulated by the expression of Snail and Twist. HPL downregulated Snail and Twist, an effect that was enhanced by TGF-β. These findings provide novel evidence that HPL suppresses cancer cell migration and invasion by inhibiting EMT. Therefore, HPL may be a potent anticancer agent, inhibiting metastasis. |
| Databáze: | OpenAIRE |
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