Newly-diagnosed pediatric epilepsy is associated with elevated autoantibodies to glutamic acid decarboxylase but not cardiolipin
| Autor: | Kaja Metsküla, Eve Õiglane-Šlik, Ulvi Vaher, Aili Traat, Raivo Uibo, Tiina Talvik, Oivi Uibo, Kadi Veri, Inga Talvik, Reet Rein, Anneli Kolk, Aita Napa |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Pathology Adolescent Cardiolipins Glutamate decarboxylase Gastroenterology 03 medical and health sciences Epilepsy Young Adult 0302 clinical medicine 030225 pediatrics Internal medicine medicine Humans Clinical significance Prospective Studies Young adult Prospective cohort study Child Autoantibodies medicine.diagnostic_test biology business.industry Glutamate Decarboxylase Autoantibody Infant Magnetic resonance imaging medicine.disease 3. Good health Neurology Child Preschool biology.protein Female Neurology (clinical) Antibody business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Epilepsy Research |
| ISSN: | 1872-6844 |
| Popis: | Glutamic acid decarboxylase autoantibodies (GADA) and anti-cardiolipin autoantibodies (ACA) have been detected in adult subjects with epilepsy, though the functional implications of these findings are a matter of debate. This study aimed to determine the prevalence of GADA and ACA and to investigate their clinical significance in pediatric subjects with newly-diagnosed epilepsy. For this purpose GADA and ACA were assessed by enzyme-linked immunosorbent assays in 208 pediatric patients with newly-diagnosed epilepsy and 128 controls. The clinical data (results of electroencephalography, magnetic resonance imaging, 6-month outcome etc.) was compared to antibody test results. Our study revealed GADA in 14 (6.7%) patients with epilepsy and in 1 (0.8%) control, which was a statistically significant difference (P=0.010; Chi-square test). The GADA-positive and -negative patients had similar clinical characteristics. The prevalence of ACA in patients with epilepsy (6.3%) was not significantly different than controls (2.6%). These results suggest that GADA is associated with epilepsy in a subgroup of newly-diagnosed pediatric patients. Further studies are required to determine the prognostic significance and pathogenic role of GADA among pediatric subjects with epilepsy. |
| Databáze: | OpenAIRE |
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