Defective cortical drive to muscle in Parkinson's disease and its improvement with levodopa
| Autor: | Seppo Kaakkola, Riitta Hari, Sari Avikainen, Stephan Salenius, Peter Brown |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Levodopa Parkinson's disease Electromyography Efferent Pathways Basal Ganglia Central nervous system disease Antiparkinson Agents Anterior Horn Cells Biological Clocks Internal medicine Basal ganglia medicine Humans Cortical Synchronization Muscle Skeletal Aged medicine.diagnostic_test Motor Cortex Magnetoencephalography Parkinson Disease Recovery of Function Middle Aged medicine.disease nervous system diseases medicine.anatomical_structure Treatment Outcome Cardiology Female Neurology (clinical) Primary motor cortex Psychology Neuroscience medicine.drug Motor cortex Muscle Contraction |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0006-8950 |
| Popis: | We recorded whole-scalp magnetoencephalographic (MEG) signals simultaneously with surface electromyographic (EMG) activity from eight patients with Parkinson's disease after withdrawal and reinstatement of treatment with levodopa. Variations were seen in the coherence between the forearm extensor EMG and the MEG signal originating near or in the hand region of the primary motor cortex. As a group, the parkinsonian patients withdrawn from levodopa showed a reduction in the coherence at 15-30 Hz and 35-60 Hz, and a further three untreated patients had abnormally strong MEG-EMG coherence at 5-12 Hz compared with when medicated or with eight healthy age-matched control subjects. We conclude that the basal ganglia have a specific effect on the temporal organization of motor cortical activity during voluntary tonic contraction. Abnormalities in this aspect of basal ganglia function may directly contribute to bradykinesia and weakness in Parkinson's disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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