Pharmacokinetics and Biodistribution of Eriocitrin in Rats
| Autor: | John A. Manthey, Thais Borges Cesar, Paula Scanavez Ferreira, Marina S. Nery |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp), USDA |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Urine Pharmacology medicine.disease_cause 01 natural sciences chemistry.chemical_compound Glucuronides Pharmacokinetics medicine Animals Tissue Distribution biodistribution Chromatography High Pressure Liquid metabolites Homoeriodictyol 010401 analytical chemistry Hesperetin General Chemistry Eriodictyol eriocitrin 0104 chemical sciences Bioavailability Rats Oxidative Stress chemistry Flavanones identification General Agricultural and Biological Sciences Eriocitrin pharmacokinetics Oxidative stress 010606 plant biology & botany |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2021-06-25T10:52:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-17 Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h and analyzed by HPLC-PDA-MS. For the first time, the metabolism and distribution of orally administered eriocitrin were shown. Nine metabolites of eriocitrin were identified in rat urine, and seven in various tissues (eriodictyol, homoeriodictyol, hesperetin, and glucuronidated metabolites), and preliminary identifications of these metabolites are suggested. Overall, eriocitrin metabolites were widely distributed in the rat tissues, where homoeriodictyol and homoeriodictyol-7-O-glucuronide were the major metabolites. The half-lives of the metabolites in plasma were between 3 and 3.2 h, and the total bioavailability of eriocitrin was less than 1%. Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Departamento de Alimentos e Nutrição, Rodovia Araraquara - Jau, km 1 U.S. Horticultural Research Laboratory Agricultural Research Service USDA, 2001 South Rock Road Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Departamento de Alimentos e Nutrição, Rodovia Araraquara - Jau, km 1 |
| Databáze: | OpenAIRE |
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