6-Aminochrysene Kinetics in Isolated Perfused Liver

Autor:	S. Villa, Ivan Bartošek, Silvio Garattini, Amalia Guaitani, R. Russo
Rok vydání:	1976
Předmět:	Male Pharmacology Liver perfusion Health Toxicology and Mutagenesis Kinetics General Medicine Metabolism Phenanthrenes Biology Toxicology Biochemistry Rats Liver Spectrophotometry Perfused liver Animals Bile Distribution (pharmacology) 6-aminochrysene Carcinoma 256 Walker Perfusion
Zdroj:	Xenobiotica. 6:473-480
ISSN:	1366-5928 0049-8254
DOI:	10.3109/00498257609151660
Popis:	1. New quantitative assays of 6-aminochrysene by spectrophotometric and g.l.c. methods and t.l.c. separation systems are described. 2. The decline in blood levels of the antitumoral agent 6-aminochrysene was due to its distribution rather than to metabolism to polar metabolites, during liver perfusion experiments. 3. No marked changes in kinetics of 6-aminochrysene were observed during perfusion of livers isolated both from normal and from Walker 256 carcinosarcoma-bearing rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a294eedb492d4be5f9d9529eed41144 https://doi.org/10.3109/00498257609151660 Zobrazit plný text záznamu