GPR56 S4 variant is required for microglia‐mediated synaptic pruning

Autor: Tao Li, Rong Luo, Rachael Schmidt, Nicholas D'Alessandro, Priya Kishore, Beika Zhu, Diankun Yu, Xianhua Piao
Rok vydání: 2022
Předmět:
Zdroj: Glia. 71:560-570
ISSN: 1098-1136
0894-1491
DOI: 10.1002/glia.24293
Popis: ADGRG1 (also called GPR56) plays critical roles in brain development and wiring, including cortical lamination, central nervous system (CNS) myelination, and developmental synaptic refinement. However, the underlying mechanism(s) in mediating such diverse functions is not fully understood. Here, we investigate the function of one specific alternative splicing isoform, the GPR56 splice variant 4 (S4), to test the hypothesis that alternative splicing variants of GPR56 in part support its different functions. We created a new transgenic mouse line, Gpr56
Databáze: OpenAIRE
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