Interventions Based on the Possibility That Oxidative Stress Contributes to Sarcopenia
| Autor: | R. S. Schwartz, R. Weindruch |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Calorie restricted diet
Aging medicine.medical_specialty Antioxidant Free Radicals medicine.medical_treatment Muscle Fibers Skeletal Physical Exertion Physical activity medicine.disease_cause Antioxidants Animals Genetically Modified Oxygen Consumption Animal model Stress Physiological Internal medicine medicine Animals Humans Muscle Skeletal Neurons business.industry Skeletal muscle medicine.disease Intervention studies Disease Models Animal Muscular Atrophy Oxidative Stress Endocrinology medicine.anatomical_structure Biochemistry Sarcopenia Body Composition Geriatrics and Gerontology Energy Intake business Oxidative stress |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :157-161 |
| ISSN: | 1758-535X 1079-5006 |
| Popis: | Skeletal muscle is a tissue which accounts for a large part of the body's total oxygen consumption at rest, due to its large mass and the majority of oxygen consumption during vigorous physical activity. Also, skeletal muscle and nervous tissues do not possess the very high repair capacities that occur in more mitotically active tissues. Accordingly, oxidative stress may accumulate with age in these tissues and contribute to the development of sarcopenia; however, this possibility has not been thoroughly investigated. Although long-term intervention studies which test the hypothesis that oxidative stress contributes to sarcopenia have not been conducted, recent findings using the caloric restriction (CR) paradigm for studying retarded aging processes indirectly support this concept. Several research directions appear important to pursue, including the measurement of free radical production in skeletal muscle at diverse ages, antioxidant supplementation as an intervention for retarding the development of sarcopenia, the use of genetically manipulated animal models, and determining the influence of CR on oxidative stress in specific skeletal muscles and individual fibers and neurons therein. |
| Databáze: | OpenAIRE |
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