Roles for sleep in memory: insights from the fly
| Autor: | Jeffrey M. Donlea |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Neurons Extramural General Neuroscience Diptera Sleep regulation Brain Model system Biology Sleep in non-human animals Homeostatic Process Article 03 medical and health sciences Neural activity 030104 developmental biology 0302 clinical medicine Hardware_GENERAL Memory Synapses Animals Memory acquisition Animal species Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current opinion in neurobiology. 54 |
| ISSN: | 1873-6882 |
| Popis: | Sleep has been universally conserved across animal species. The basic functions of sleep remain unclear, but insufficient sleep impairs memory acquisition and retention in both vertebrates and invertebrates. Sleep is also a homeostatic process that is influenced not only by the amount of time awake, but also by neural activity and plasticity. Because of the breadth and precision of available genetic tools, the fruit fly has become a powerful model system to understand sleep regulation and function. Importantly, these tools enable the dissection of memory-encoding circuits at the level of individual neurons, and have allowed the development of genetic tools to induce sleep on-demand. This review describes recent investigations of the role for sleep in memory using Drosophila and current hypotheses of sleep's functions for supporting plasticity, learning, and memory. |
| Databáze: | OpenAIRE |
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