Acute renal failure in children. Multicenter prospective cohort study in medium-complexity intensive care units from the Colombian southeast

Autor: Stefany Tetay, Jaime Manuel Restrepo, Mónica V. Mondragon, Yessica Bravo, Eliana Zemanate, Rubén E. Lasso, Jessica María Forero-Delgadillo, Gastón E. Castillo, José Andrés Calvache, Natalia Cabal
Přispěvatelé: Anesthesiology
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Epidemiology
medicine.medical_treatment
030232 urology & nephrology
Kaplan-Meier Estimate
Severity of Illness Index
Pediatrics
Biochemistry
Geographical locations
0302 clinical medicine
Prevalence
Medicine and Health Sciences
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Child
Pediatric Epidemiology
Pediatric intensive care unit
Multidisciplinary
Mortality rate
Acute kidney injury
Acute Kidney Injury
Prognosis
Hospitals
Renal Replacement Therapy
Treatment Outcome
Nephrology
Child
Preschool
Creatinine
Medicine
Female
Anatomy
Research Article
medicine.medical_specialty
Adolescent
Death Rates
Science
Colombia
Intensive Care Units
Pediatric
03 medical and health sciences
Population Metrics
Intensive care
Severity of illness
Medical Dialysis
medicine
Humans
Renal replacement therapy
Population Biology
business.industry
Infant
Newborn
Infant
Biology and Life Sciences
Kidneys
Renal System
Length of Stay
South America
medicine.disease
Respiration
Artificial
Health Care
Health Care Facilities
Emergency medicine
People and places
business
Biomarkers
Kidney disease
Zdroj: PLoS ONE, Vol 15, Iss 8, p e0235976 (2020)
PLoS One (print), 15(8):e0235976. Public Library of Science
PLoS ONE
ISSN: 1932-6203
Popis: BackgroundAcute kidney injury is frequent in critically ill children; however, it varies in causality and epidemiology according to the level of patient care complexity. A multicenter prospective cohort study was conducted in four medium-complexity pediatric intensive care units from the Colombian southeast aimed to estimate the clinical prognosis of patients with diagnosis of acute kidney injury.MethodsWe included children >28 days and ResultsPrevalence at admission of acute kidney injury was 5.2% (95%CI 4.3% to 6.2%). It was found that 71% of the patients had their maximum KDIGO on day one; an increment in the maximum stage of acute kidney injury increased the pediatric intensive care unit stay. Patients with maximum KDIGO 3 were associated with greater use of mechanical ventilation (47%), compared with maximum KDIGO 2 (37%) and maximum KDIGO 1 (16%). Eight patients with maximum KDIGO 2 and 14 with maximum KDIGO 3 required renal replacement therapy. Mortality was at 11.8% (95%CI 6.4% to 19.4%).ConclusionAcute kidney injury, established and classified according to KDIGO as severe and its maximum stage, was associated with worse clinical outcomes; early therapeutic efforts should focus on preventing the progression to severe stages.
Databáze: OpenAIRE
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