Organoplatinum(II) Complexes as a Color Biomarker in Solid-Phase Peptide Chemistry and Screening
| Autor: | Guido D. Batema, G. van Koten, Koen M. Halkes, Johannis P. Kamerling, G. Guillena Townley, G. Rodriguez Longarella |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
chemistry.chemical_classification
Organoplatinum Compounds Combinatorial Chemistry Techniques Organic Chemistry Color Peptide Biochemistry Combinatorial chemistry Biomarker Enzyme chemistry Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Phase (matter) Amine gas treating Amino Acid Sequence Physical and Theoretical Chemistry Peptides Peptide sequence Organoplatinum Biomarkers |
| Zdroj: | Organic Letters. 5:2021-2024 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol034337s |
| Popis: | [reaction: see text] A novel organoplatinum(II) biomarker is introduced to facilitate the solid-phase screening of combinatorial libraries for substrates and inhibitors of enzymes and receptors. The robust organoplatinum(II) biomarker can be incorporated, on amine functions, in peptides using standard peptide coupling techniques. The chemistry, stability, and (reversible) coloration process with KI(3) of the organoplatinum(II) biomarker was investigated. |
| Databáze: | OpenAIRE |
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