Combined analysis of data from two granddaughter designs: a simple strategy for QTL confirmation and increasing experimental power in dairy cattle
Autor: | Jörn Bennewitz, C. Weimann, Christian Looft, Ingolf Russ, N. Xu, Georg Erhardt, Stefan Hiendleder, Cécile Grohs, I. Medjugorac, G. Averdunk, Manfred Schwerin, Christa Kühn, F. Reinhardt, Hauke Thomsen, Ernst Kalm, J. Blümel, R. Reents, Norbert Reinsch, Hubert Levéziel, A. Malafosse, Gudrun A. Brockmann, Bertram Brenig, Didier Boichard, M. Förster |
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Přispěvatelé: | Unité de recherche Génétique Biochimique et Cytogénétique (LGBC), Institut National de la Recherche Agronomique (INRA), Unité de Génétique Moléculaire Animale (UGMA), Université de Limoges (UNILIM)-Institut National de la Recherche Agronomique (INRA), Station de Génétique Quantitative et Appliquée (SGQA), Unité de Génétique Moléculaire Animale (UMR GMA), Institut National de la Recherche Agronomique (INRA)-Université de Limoges (UNILIM) |
Jazyk: | angličtina |
Rok vydání: | 2003 |
Předmět: |
Genetic Markers
lcsh:QH426-470 [SDV]Life Sciences [q-bio] Quantitative Trait Loci Quantitative trait locus Biology GRANDDAUGHTER DESIGN 03 medical and health sciences ANALYSE CONJOINTE Granddaughter Chromosome 19 Genetics Animals Genetics(clinical) Dairy cattle Ecology Evolution Behavior and Systematics 030304 developmental biology lcsh:SF1-1100 0303 health sciences Models Genetic Research Sire QTL confirmation 0402 animal and dairy science Chromosome food and beverages Chromosome Mapping 04 agricultural and veterinary sciences General Medicine Quantitative genetics 040201 dairy & animal science QTL MAPPING COMBINED ANALYSIS DAIRY CATTLE PROTOCOLE PETITES-FILLES Pedigree lcsh:Genetics Dairying bovin laitier détection de qtl Genetic marker Data Interpretation Statistical Animal Science and Zoology Cattle Female lcsh:Animal culture |
Zdroj: | Genetics Selection Evolution Genetics Selection Evolution, BioMed Central, 2003, 35, pp.319-338 Genetics, Selection, Evolution : GSE Scopus-Elsevier Genetics Selection Evolution, Vol 35, Iss 3, Pp 319-338 (2003) Genetics Selection Evolution (35), 319-338. (2003) |
ISSN: | 0999-193X 1297-9686 |
Popis: | A joint analysis of five paternal half-sib Holstein families that were part of two different granddaughter designs (ADR- or Inra-design) was carried out for five milk production traits and somatic cell score in order to conduct a QTL confirmation study and to increase the experimental power. Data were exchanged in a coded and standardised form. The combined data set (JOINT-design) consisted of on average 231 sires per grandsire. Genetic maps were calculated for 133 markers distributed over nine chromosomes. QTL analyses were performed separately for each design and each trait. The results revealed QTL for milk production on chromosome 14, for milk yield on chromosome 5, and for fat content on chromosome 19 in both the ADR- and the Inra-design (confirmed within this study). Some QTL could only be mapped in either the ADR- or in the Inra-design (not confirmed within this study). Additional QTL previously undetected in the single designs were mapped in the JOINT-design for fat yield (chromosome 19 and 26), protein yield (chromosome 26), protein content (chromosome 5), and somatic cell score (chromosome 2 and 19) with genomewide significance. This study demonstrated the potential benefits of a combined analysis of data from different granddaughter designs. |
Databáze: | OpenAIRE |
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