Combined analysis of data from two granddaughter designs: a simple strategy for QTL confirmation and increasing experimental power in dairy cattle

Autor: Jörn Bennewitz, C. Weimann, Christian Looft, Ingolf Russ, N. Xu, Georg Erhardt, Stefan Hiendleder, Cécile Grohs, I. Medjugorac, G. Averdunk, Manfred Schwerin, Christa Kühn, F. Reinhardt, Hauke Thomsen, Ernst Kalm, J. Blümel, R. Reents, Norbert Reinsch, Hubert Levéziel, A. Malafosse, Gudrun A. Brockmann, Bertram Brenig, Didier Boichard, M. Förster
Přispěvatelé: Unité de recherche Génétique Biochimique et Cytogénétique (LGBC), Institut National de la Recherche Agronomique (INRA), Unité de Génétique Moléculaire Animale (UGMA), Université de Limoges (UNILIM)-Institut National de la Recherche Agronomique (INRA), Station de Génétique Quantitative et Appliquée (SGQA), Unité de Génétique Moléculaire Animale (UMR GMA), Institut National de la Recherche Agronomique (INRA)-Université de Limoges (UNILIM)
Jazyk: angličtina
Rok vydání: 2003
Předmět:
Genetic Markers
lcsh:QH426-470
[SDV]Life Sciences [q-bio]
Quantitative Trait Loci
Quantitative trait locus
Biology
GRANDDAUGHTER DESIGN
03 medical and health sciences
ANALYSE CONJOINTE
Granddaughter
Chromosome 19
Genetics
Animals
Genetics(clinical)
Dairy cattle
Ecology
Evolution
Behavior and Systematics
030304 developmental biology
lcsh:SF1-1100
0303 health sciences
Models
Genetic
Research
Sire
QTL confirmation
0402 animal and dairy science
Chromosome
food and beverages
Chromosome Mapping
04 agricultural and veterinary sciences
General Medicine
Quantitative genetics
040201 dairy & animal science
QTL MAPPING
COMBINED ANALYSIS
DAIRY CATTLE
PROTOCOLE PETITES-FILLES
Pedigree
lcsh:Genetics
Dairying
bovin laitier
détection de qtl
Genetic marker
Data Interpretation
Statistical
Animal Science and Zoology
Cattle
Female
lcsh:Animal culture
Zdroj: Genetics Selection Evolution
Genetics Selection Evolution, BioMed Central, 2003, 35, pp.319-338
Genetics, Selection, Evolution : GSE
Scopus-Elsevier
Genetics Selection Evolution, Vol 35, Iss 3, Pp 319-338 (2003)
Genetics Selection Evolution (35), 319-338. (2003)
ISSN: 0999-193X
1297-9686
Popis: A joint analysis of five paternal half-sib Holstein families that were part of two different granddaughter designs (ADR- or Inra-design) was carried out for five milk production traits and somatic cell score in order to conduct a QTL confirmation study and to increase the experimental power. Data were exchanged in a coded and standardised form. The combined data set (JOINT-design) consisted of on average 231 sires per grandsire. Genetic maps were calculated for 133 markers distributed over nine chromosomes. QTL analyses were performed separately for each design and each trait. The results revealed QTL for milk production on chromosome 14, for milk yield on chromosome 5, and for fat content on chromosome 19 in both the ADR- and the Inra-design (confirmed within this study). Some QTL could only be mapped in either the ADR- or in the Inra-design (not confirmed within this study). Additional QTL previously undetected in the single designs were mapped in the JOINT-design for fat yield (chromosome 19 and 26), protein yield (chromosome 26), protein content (chromosome 5), and somatic cell score (chromosome 2 and 19) with genomewide significance. This study demonstrated the potential benefits of a combined analysis of data from different granddaughter designs.
Databáze: OpenAIRE
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