Antimicrobial Agent Dosing in Infants
| Autor: | Jacob K. Johnson, Matthew M. Laughon |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antifungal Agents medicine.drug_class 030106 microbiology Antibiotics Pharmacology Kidney Antiviral Agents Drug Administration Schedule 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents Pharmacokinetics 030225 pediatrics Drug Discovery Humans Medicine Pharmacology (medical) Dosing Intensive care medicine Volume of distribution Dose-Response Relationship Drug business.industry Infant Newborn Infant Antimicrobial Anti-Bacterial Agents Liver Drug development business Infant Premature Drug metabolism |
| Zdroj: | Clinical Therapeutics. 38:1948-1960 |
| ISSN: | 0149-2918 |
| Popis: | Purpose The goal of this article was to review infant physiology and its effects on the pharmacokinetic properties of antimicrobial agents. Methods A review of the drug development process was performed. A literature search was conducted on the pharmacokinetics of various antimicrobial agents in infants. Findings The pharmacokinetic properties of antimicrobial agents in infants are most often affected by the renal maturation of premature infants. Hepatic metabolism and volume of distribution play a common role as well. Implications The dosing and dosing intervals of various medications were reviewed and compared with details of adult dosing. It is vital to continue to gather pharmacokinetic data in infants to ensure adequate safety and dosing of medications. |
| Databáze: | OpenAIRE |
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