Immunity to pre-1950 H1N1 influenza viruses confers cross-protection against the pandemic swine-origin 2009 A (H1N1) influenza virus
| Autor: | Ioanna Skountzou, Joshy Jacob, Robert S. Mittler, Maria del Pilar Martin, Dimitrios G. Koutsonanos, Lakshmipriyadarshini Satyabhama, Feda Masseoud, William C. Weldon, Jin Hyang Kim, Richard W. Compans, Ryan Powers |
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| Rok vydání: | 2010 |
| Předmět: |
viruses
Cross Protection Immunology Cross immunity Biology medicine.disease_cause Antibodies Viral H5N1 genetic structure Virus Article Disease Outbreaks Mice Influenza A Virus H1N1 Subtype Orthomyxoviridae Infections Pandemic Influenza A virus medicine Immunology and Allergy Animals Humans Mice Inbred BALB C Antigenic shift virus diseases Hemagglutination Inhibition Tests Virology Influenza A virus subtype H5N1 respiratory tract diseases Influenza Vaccines Immunoglobulin G Human mortality from H5N1 |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 185(3) |
| ISSN: | 1550-6606 |
| Popis: | The 2009 H1N1 influenza virus outbreak is the first pandemic of the twenty-first century. Epidemiological data reveal that of all the people afflicted with H1N1 virus, 60 y old have pre-existing neutralizing Abs against the 2009 H1N1 virus. This finding suggests that influenza strains that circulated 50–60 y ago might provide cross-protection against the swine-origin 2009 H1N1 influenza virus. To test this, we determined the ability of representative H1N1 influenza viruses that circulated in the human population from 1930 to 2000, to induce cross-reactivity to and cross-protection against the pandemic swine-origin H1N1 virus, A/California/04/09. We show that exposure of mice to the 1947 virus, A/FM/1/47, or the 1934 virus, A/PR/8/34, induced robust cross-protective immune responses and these mice were protected against a lethal challenge with mouse-adapted A/California/04/09 H1N1 virus. Conversely, we observed that mice exposed to the 2009 H1N1 virus were protected against a lethal challenge with mouse-adapted 1947 or 1934 H1N1 viruses. In addition, exposure to the 2009 H1N1 virus induced broad cross-reactivity against H1N1 as well as H3N2 influenza viruses. Finally, we show that vaccination with the older H1N1 viruses, particularly A/FM/1/47, confers protective immunity against the 2009 pandemic H1N1 virus. Taken together, our data provide an explanation for the decreased susceptibility of the elderly to the 2009 H1N1 outbreak and demonstrate that vaccination with the pre-1950 influenza strains can cross-protect against the pandemic swine-origin 2009 H1N1 influenza virus. |
| Databáze: | OpenAIRE |
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