A derivative of a rigid glutamate analog protects the retina from excitotoxicity
| Autor: | Renata Siliprandi, Maria Lipartiti, Emanuela Fadda, Roberto Arban, Hari Manev, Alan P. Kozikowski |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Excitotoxicity Biology medicine.disease_cause Eye Receptors Metabotropic Glutamate Neuroprotection Choline O-Acetyltransferase Injections Rats Sprague-Dawley Glutamates Retinal Diseases Internal medicine medicine Neurotoxin Animals General Neuroscience Glutamate receptor Choline acetyltransferase Rats medicine.anatomical_structure Endocrinology nervous system Metabotropic glutamate receptor Biophysics NMDA receptor Neuron Azetidinecarboxylic Acid |
| Zdroj: | Neuroreport. 5(10) |
| ISSN: | 0959-4965 |
| Popis: | In the retina, the activation of metabotropic glutamate receptors (mGluRs) reduces the toxic effect of N-methyl-D-aspartate (NMDA). We have induced NMDA-mediated excitotoxicity in the adult rat retina by a single intraocular injection of NMDA. The damage that resulted was estimated by assessing the NMDA-induced loss of retinal choline acetyltransferase (ChAT) activity. The new rigid glutamate analog, dimethyl ester of (+/-)-trans-azetidine-2,4-dicarboxylic acid (t-DMADA), with a putative mGluR-agonistic activity, protected the retina from NMDA-induced loss of ChAT activity. This study demonstrated that t-DMADA can be considered a prototype of new retino-protective agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|