Therapeutic potentials and modulatory mechanisms of fatty acids in bone
| Autor: | Ling Ye, Yanzi Gao, Yangyini Wei, Kaiwen Zhang, Weihan Hua, Minyue Bao, Xin Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell type bone homeostasis Reviews Osteoclasts Review Article Bone marrow mesenchymal stem cells Bone and Bones Bone remodeling 03 medical and health sciences 0302 clinical medicine Osteogenesis Bone cell Animals Humans Bone formation chemistry.chemical_classification Osteoblasts Chemistry Fatty Acids Mesenchymal Stem Cells Cell Biology General Medicine Resorption 030104 developmental biology bone diseases Biochemistry 030220 oncology & carcinogenesis bone metabolism Energy Metabolism Polyunsaturated fatty acid |
| Zdroj: | Cell Proliferation |
| ISSN: | 1365-2184 0960-7722 |
| Popis: | Bone metabolism is a lifelong process that includes bone formation and resorption. Osteoblasts and osteoclasts are the predominant cell types associated with bone metabolism, which is facilitated by other cells such as bone marrow mesenchymal stem cells (BMMSCs), osteocytes and chondrocytes. As an important component in our daily diet, fatty acids are mainly categorized as long‐chain fatty acids including polyunsaturated fatty acids (LCPUFAs), monounsaturated fatty acids (LCMUFAs), saturated fatty acids (LCSFAs), medium‐/short‐chain fatty acids (MCFAs/SCFAs) as well as their metabolites. Fatty acids are closely associated with bone metabolism and associated bone disorders. In this review, we summarized the important roles and potential therapeutic implications of fatty acids in multiple bone disorders, reviewed the diverse range of critical effects displayed by fatty acids on bone metabolism, and elucidated their modulatory roles and mechanisms on specific bone cell types. The evidence supporting close implications of fatty acids in bone metabolism and disorders suggests fatty acids as potential therapeutic and nutritional agents for the treatment and prevention of metabolic bone diseases. |
| Databáze: | OpenAIRE |
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