Optimization of nutrition during allogeneic hematologic stem cell transplantation
| Autor: | Katja Hoskin, Philipp Schuetz, Annic Baumgartner |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Oncology
Parenteral Nutrition medicine.medical_specialty Neutropenia medicine.medical_treatment MEDLINE Nutritional Status Medicine (miscellaneous) Hematopoietic stem cell transplantation Infections 03 medical and health sciences Enteral Nutrition 0302 clinical medicine Internal medicine Humans Medicine In patient Risk factor Nutrition and Dietetics business.industry Malnutrition Hematopoietic Stem Cell Transplantation medicine.disease Diet Transplantation surgical procedures operative Parenteral nutrition 030220 oncology & carcinogenesis Stem cell business 030215 immunology |
| Zdroj: | Current Opinion in Clinical Nutrition & Metabolic Care. 21:152-158 |
| ISSN: | 1363-1950 |
| DOI: | 10.1097/mco.0000000000000461 |
| Popis: | Malnutrition before and during hematopoietic stem cell transplantation (HSCT) is an independent risk factor for mortality in patients undergoing hematopoietic stem cell transplantation. Yet, optimal use of nutritional support to improve outcomes remains controversial. Our aim was to do an up-to-date literature review regarding nutritional therapy in allogeneic HSCT, the neutropenic diet and the use of immunonutrients.Several observational studies find malnutrition to be associated with poor outcome, increased complications and lower overall survival. There are, however, few interventional trials proving the benefits of nutritional therapy in this population compared with no nutritional treatment. Regarding routes of treatment, studies suggested that parenteral nutrition is associated with higher risk for complications compared with enteral nutrition. Whether the use of specific formulas, such as immunonutrition, has a beneficial effect on clinical outcome is not established yet. Strict use of neutropenic diets did not show a reduction in infection risk and clinical outcome, and can no longer be recommended.Our updated search confirms that malnutrition is a strong negative predictor for outcome, yet optimal use of nutritional interventions to prevent or treat malnutrition remains ill-defined. There is need for larger randomized trials to better address these issues in the future. |
| Databáze: | OpenAIRE |
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