A mouse model of orthotopic vascularized aerated lung transplantation
| Autor: | C.G. Kornfeld, Alexander S. Krupnick, Howard J. Huang, Daniel Kreisel, Jon H. Ritter, Nitin A. Das, S.B. Richardson, G.A. Patterson, Mikio Okazaki, Andrew E. Gelman, J. Lai |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Pulmonary Circulation Ratón medicine.medical_treatment Pulmonary Artery Mice Immunology and Allergy Medicine Lung transplantation Animals Pharmacology (medical) Respiratory system Antigen-presenting cell Transplantation Lung business.industry respiratory system medicine.disease respiratory tract diseases Mice Inbred C57BL Transplantation Isogeneic surgical procedures operative medicine.anatomical_structure Pulmonary Veins Models Animal Solid organ business Infiltration (medical) Lung Transplantation |
| Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7(6) |
| ISSN: | 1600-6135 |
| Popis: | Outcomes after lung transplantation are markedly inferior to those after other solid organ transplants. A better understanding of cellular and molecular mechanisms contributing to lung graft injury will be critical to improve outcomes. Advances in this field have been hampered by the lack of a mouse model of lung transplantation. Here, we report a mouse model of vascularized aerated single lung transplantation utilizing cuff techniques. We show that syngeneic grafts have normal histological appearance with minimal infiltration of T lymphocytes. Allogeneic grafts show acute cellular rejection with infiltration of T lymphocytes and recipient-type antigen presenting cells. Our data show that we have developed a physiological model of lung transplantation in the mouse, which provides ample opportunity for the study of nonimmune and immune mechanisms that contribute to lung allograft injury. |
| Databáze: | OpenAIRE |
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