Regulatory effects of autophagy on spermatogenesis
| Autor: | Fan Yang, Yu-Qi Gao, Wei-Gong Liao, Zhiqiang Tian, Jun Yin, Bing Ni |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Spermatogenic Cell PDZ domain Autophagy Cell Biology General Medicine Abnormal spermatogenesis Biology Sertoli cell Cell biology 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Reproductive Medicine Apoptosis medicine Humans Spermatogenesis LIM domain |
| Zdroj: | Biology of reproduction. 96(3) |
| ISSN: | 1529-7268 |
| Popis: | Abnormal spermatogenesis is an important pathophysiological process underlying male infertility. Apoptosis of spermatogenic cells and disruption of ectoplasmic specialization (ES) have been characterized as the key biological events of this disorder. Under physiological and pathophysiological conditions (such as exposure to starvation, environmental chemicals, radiation), autophagy is activated in spermatogenic or Sertoli cells in order to maintain survival of the spermatogenic cells by inhibiting spermatogenic cell apoptosis and stabilizing the integrity of ES via degradation of PDZ and LIM domain 1 (PDLIM1), a negative regulator of cytoskeletal organization. Here, we review the most recent research progress towards understanding the pivotal effects of autophagy on spermatogenesis. |
| Databáze: | OpenAIRE |
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