Trimethylamine N-oxide is a new plant molecule that promotes abiotic stress tolerance
| Autor: | Rosa Lopez-Cobollo, Jesús Jiménez-Barbero, M. Álvaro Berbís, Rafael Catalá, Julio Salinas |
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| Přispěvatelé: | Agencia Estatal de Investigación (España), European Commission, Ministerio de Ciencia e Innovación (España), Catalá, Rafael [0000-0002-8668-7434], López-Cobollo, Rosa María [0000-0002-4392-5893], Berbís, Manuel Álvaro [0000-0002-0331-7762], Jiménez-Barbero, Jesús [0000-0001-5421-8513], Salinas, Julio [0000-0003-2020-0950], Catalá, Rafael, López-Cobollo, Rosa María, Berbís, Manuel Álvaro, Jiménez-Barbero, Jesús, Salinas, Julio |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Abiotic component 0303 health sciences Multidisciplinary Activator (genetics) Chemistry Abiotic stress Plant Sciences food and beverages Trimethylamine SciAdv r-articles Trimethylamine N-oxide Monooxygenase 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Biochemistry Osmolyte Protein folding Research Articles 030304 developmental biology 010606 plant biology & botany Research Article |
| Zdroj: | Science Advances Digital.CSIC: Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 2375-2548 |
| Popis: | 12 p.-6 fig. Trimethylamine N-oxide (TMAO) is a well-known naturally occurring osmolyte in animals that counteracts the effect of different denaturants related to environmental stress and has recently been associated with severe human chronic diseases. In plants, however, the presence of TMAO has not yet been reported. In this study, we demonstrate that plants contain endogenous levels of TMAO, that it is synthesized by flavin-containing mono-oxygenases, and that its levels increase in response to abiotic stress conditions. In addition, our results reveal that TMAO operates as a protective osmolyte in plants, promoting appropriate protein folding and as an activator of abiotic stress–induced gene expression. Consistent with these functions, we show that TMAO enhances plant adaptation to low temperatures, drought, and high salt. We have thus uncovered a previously unidentified plant molecule that positively regulates abiotic stress tolerance. Research in the Salinas laboratory was supported by grants BIO2016-79187-R from AEI/FEDER, UE, and PID2019-106987RB-100/AEI/10.13039/5011033. |
| Databáze: | OpenAIRE |
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