Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?
| Autor: | Mariya Marushchak, V. V. Shcherba, Inna Krynytska, M. M. Korda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty endocrine system Lipopolysaccharide endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyroid Gland Inflammation Diseases of the endocrine glands. Clinical endocrinology chemistry.chemical_compound Endocrinology Internal medicine medicine Animals hyperthyroidism Euthyroid periodontitis Periodontitis business.industry Tumor Necrosis Factor-alpha Interleukin Periodontium medicine.disease RC648-665 rats Cytokine chemistry inflammation Tumor necrosis factor alpha hypothyroidism medicine.symptom Inflammation Mediators business |
| Zdroj: | Endocrine Regulations, Vol 55, Iss 3, Pp 131-141 (2021) |
| ISSN: | 1336-0329 |
| Popis: | Objective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12–14 weeks old inbred rats (n=48) weighing 180–200 g were employed in the experiment. They were randomly divided into the following groups: Group I – control group, Group II – group with a model of periodontitis, Group III – group with a periodontitis in a setting of hyperthyroidism, and Group IV – group with periodontitis in a setting of hypothyroidism. The presence of tumor-necrosis factor-α (TNF-α) and interleukins IL-1β and IL-10 in the periodontal homogenate supernatant was studied by a solid-phase enzyme-linked immunosorbent assay. Results. It was shown that experimental lipopolysaccharide (LPS)-induced periodontitis is accompanied by hyperproduction of pro-inflammatory cytokines (TNF-α, IL-1β) and reduction of anti-inflammatory cytokines (IL-10), whereas TNF-α underwent to maximum changes. Thyroid dysfunction exacerbates cytokine imbalance and severity of inflammation in experimental LPS-induced periodontitis, especially pronounced at hyperthyroidism, as evidenced by the predominance of TNF-α and IL-1β levels in the periodontal homogenate supernatant by 38.5% (р Conclusions. Thyroid dysfunction, especially hyperthyroidism, may play an important role in the pro-inflammatory response in periodontitis. Hyperproduction of inflammatory mediators in thyroid dysfunction can induce a noticeable damage in the whole apparatus of the periodontium, thereby causing progression of periodontitis. |
| Databáze: | OpenAIRE |
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