Influence of cisplatinum and 5-fluorouracil on the oral mucosa
| Autor: | J. Zöller, I. A. Born, M. Flentje, H. Osswald |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty medicine.medical_treatment Oral cavity S Phase Malignant transformation Antineoplastic Combined Chemotherapy Protocols Nucleolus Organizer Region medicine Carcinoma Humans Prospective Studies Oral mucosa Prospective cohort study Chemotherapy Epithelioma business.industry Mouth Mucosa Neoplasms Second Primary medicine.disease Cell Transformation Neoplastic medicine.anatomical_structure Oncology Fluorouracil Mouth Neoplasms Cisplatin business medicine.drug |
| Zdroj: | European Journal of Cancer Part B: Oral Oncology. 30:200-203 |
| ISSN: | 0964-1955 |
| DOI: | 10.1016/0964-1955(94)90092-2 |
| Popis: | In a prospective study we examined the effect of preoperative chemotherapy with cisplatinum and 5-fluorouracil (5FU) in 40 patients with a carcinoma of the oral cavity. Histopathological grading, cell kinetic and immuno-histochemical parameters of the mucosa were determined at two different locations. Prior to therapy histological dysplasias “close” to the tumour were observed in the mucosa of 75% of the patients. Dysplastic changes of the mucosa “far” from the tumour were also found in more than one third of the patients. Our results show that more advanced dysplasias improve under the influence of preoperative systemic chemotherapy only temporarily. Moreover, new dysplasias which appeared during chemotherapy and persisted after its termination are probably induced. |
| Databáze: | OpenAIRE |
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