A hybrid polymer to target blood group dependence of cholera toxin
| Autor: | Haksar, Diksha, Quarles Van Ufford, Linda, Pieters, Roland J., Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery |
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| Přispěvatelé: | Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery |
| Rok vydání: | 2019 |
| Předmět: |
Cholera Toxin
Polymers Enzyme-Linked Immunosorbent Assay medicine.disease_cause 01 natural sciences Biochemistry Microbiology Cell Line 03 medical and health sciences medicine Humans Physical and Theoretical Chemistry Receptor 030304 developmental biology Fucose 0303 health sciences Molecular Structure 010405 organic chemistry Toxin Chemistry Organic Chemistry Cholera toxin AB5 toxin medicine.disease Cholera 0104 chemical sciences Cell culture Vibrio cholera |
| Zdroj: | Organic and Biomolecular Chemistry, 18(1), 52. Royal Society of Chemistry |
| ISSN: | 1477-0539 1477-0520 |
| Popis: | Cholera is a potentially fatal bacterial infection caused by the cholera toxin (CT), an AB5 toxin secreted by Vibrio cholera. GM1 has long been known as the receptor of the cholera toxin in the intestine. However, increasing evidence is pointing towards the role of fucosylated conjugates as additional attachment options of the toxin. In the present paper we have synthesized a polymeric hybrid which can inhibit both modes of attachment. |
| Databáze: | OpenAIRE |
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