Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart
| Autor: | Jasenka Kraljević, Marko Ljubkovic, Jasna Marinovic, Zeljko Dujic, Petra Zubin, Danijel Pravdic, Ulrik Wisløff |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Time Factors Physiology Myocardial Infarction Infarction Biology Protein oxidation Mitochondria Heart Ventricular Function Left Interval training Rats Sprague-Dawley Left coronary artery Physiology (medical) medicine.artery Internal medicine Respiration medicine Animals Myocardial infarction Ventricular remodeling Ultrasonography Heart Failure Electron Transport Complex I Ventricular Remodeling Electron Transport Complex II Myocardium medicine.disease Myocardial Contraction Exercise Therapy Rats Surgery Disease Models Animal Heart failure aerobic training rat heart failure Cardiology Female Energy Metabolism Cardiology and Cardiovascular Medicine |
| Zdroj: | Cardiovascular Research. 99:55-64 |
| ISSN: | 1755-3245 0008-6363 |
| DOI: | 10.1093/cvr/cvt080 |
| Popis: | Aims Following a large myocardial infarction (MI), remaining viable muscle often undergoes pathological remodelling and progresses towards chronic heart failure. Mitochondria may also be affected by this process and, due to their functional importance, likely contribute to the progression of the disease. Aerobic interval training (AIT) has been shown effective in diminishing pathological myocardial transformation, but the effects of AIT on mitochondrial function in hearts undergoing remodelling are not known. Methods and results Adult female Sprague–Dawley rats were randomized to either 8 weeks of aerobic interval treadmill running (5 days/week), which started 4 weeks after left coronary artery ligation (MI-Trained), or a sedentary group (MI-Sedentary). Echocardiography was performed before and after the 8-week period, at which point the left ventricles (LVs) were also harvested. Twelve weeks after surgery, MI-Sedentary rats had significantly lower LV fractional shortening compared with MI-Trained rats. Complex I-dependent respiration assessed in isolated LV mitochondria was decreased by ∼37% in MI-Sedentary and 17% in MI-Trained animals (group differences P < 0.05), compared with sham-operated animals. This was paralleled with diminished ATP production and increased degree of protein oxidation in MI-Sedentary rats. The enzymatic activity of complex I was also decreased to a greater extent in MI-Sedentary than in MI-Trained animals, with no evidence of its reduced expression. When complex II substrate was used, no differences among the three groups were observed. Conclusion Exercise reduces LV contractile deterioration in post-infarction heart failure and alleviates the extent of mitochondrial dysfunction, which is paralleled with preserved complex I activity. |
| Databáze: | OpenAIRE |
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