Incidence of cardiovascular risk factors in female patients with systemic lupus erythematosus: a 3-year follow-up cohort

Autor:	L N Martins, Rosa Weiss Telles, Rodrigo Citton Padilha Reis, M P S Penteado, Cristina Costa Duarte Lanna, Antonio Luiz Pinho Ribeiro, Fabiana de Miranda Moura dos Santos, C S A Monção
Rok vydání:	2018
Předmět:	Adult medicine.medical_specialty Cardiovascular risk factors 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences Young Adult 0302 clinical medicine Rheumatology Prednisone Risk Factors Internal medicine Female patient medicine Humans Lupus Erythematosus Systemic Prospective Studies Dyslipidemias 030203 arthritis & rheumatology Metabolic Syndrome Systemic lupus erythematosus business.industry Incidence (epidemiology) Incidence Smoking Age Factors Middle Aged medicine.disease Logistic Models Cohort Hypertension Multivariate Analysis Female business Brazil medicine.drug Follow-Up Studies
Zdroj:	Lupus. 27(11)
ISSN:	1477-0962
Popis:	Objectives To evaluate the incidence and variability of traditional coronary artery disease (CAD) risk factors in a cohort of lupus patients and to investigate if prednisone use predicts an increase in the number of risk factors. Methods A total of 151 women, 37.8 ± 11.1 (mean ± SD) years old at baseline, were reevaluated after a median period of 39 (interquartile range 36.5–42.0) months. The cumulative incidence of traditional risk factors, the incidence rate (with 95% confidence interval) of hypertension, diabetes, dyslipidemia and hypertriglyceridemia, and the frequency of the risk factors’ disappearance were calculated. Metabolic syndrome (MetS) and Framingham risk score (FRS) were computed. Logistic regression was used to investigate if maximum or cumulative prednisone dose used during follow-up predicted an increase in the cardiometabolic risk factors’ number. Results The cumulative incidence of risk factors varied from 39.1% (abdominal obesity) to zero (smoking), and the incidence rate varied from 133.2 (87.8–178.6) per 1000 person-years (dyslipidemia) to 10.4 (1.3–19.5) per 1000 person-years (diabetes). The cumulative incidence for MetS was 18.8%, and 11.7% of 143 patients with low FRS at baseline (T1) were classified in the high-risk category at the end of the study (T2). Dyslipidemia was the most variable risk factor, with 43.5% disappearance at T2. The maximum prednisone dose used during follow-up was borderline ( p = 0.050) for prediction of an increase in the number of cardiometabolic risk factors in an adjusted model for antimalarial use, modified Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and age. Conclusion The authors described high incidence and variability of CAD risk factors in female lupus patients, with higher prednisone dose being borderline for an increase in the number of cardiometabolic risk factors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a157919788889a736ba22e81cc5b6b2 https://pubmed.ncbi.nlm.nih.gov/30099941 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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