ATP and adenosine: Role in the immunopathogenesis of rheumatoid arthritis
Autor: | Daniela B.R. Leal, Viviane M. Bernardes, Jean L.G. da Silva, Daniela F. Passos |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Adenosine Immunology Arthritis Context (language use) Pharmacology GPI-Linked Proteins Arthritis Rheumatoid 03 medical and health sciences chemistry.chemical_compound Adenosine Triphosphate 0302 clinical medicine Adenosine deaminase medicine Animals Humans Immunology and Allergy Receptor 5'-Nucleotidase biology Apyrase Purinergic receptor medicine.disease Adenosine receptor 030104 developmental biology chemistry biology.protein Receptors Purinergic P2X7 Adenosine triphosphate Biomarkers Signal Transduction 030215 immunology medicine.drug |
Zdroj: | Immunology Letters. 214:55-64 |
ISSN: | 0165-2478 |
Popis: | Rheumatoid arthritis (RA) is a classic inflammatory autoimmune disease. Local joint destruction and extra-articular manifestations of RA deeply compromise the life quality of the affected patients. RA immunopathogenesis depends on continuous immunogenic activation in which the purinergic system participates. The purinergic system comprises the signaling and metabolism of purines such as adenosine triphosphate (ATP) and adenosine. ATP signaling is involved in the activation and maintenance of the inflammatory state of RA through the activation of P2X7 and the production of cytokines, which orchestrate the pathogenesis of RA. The breakdown of ATP through the CD39/CD73 axis produces adenosine, which mostly inhibits the inflammatory process through activation of specific P1 receptors. Adenosine is hydrolyzed by adenosine deaminase (ADA) that interacts with other molecules playing additional roles in this disease. This review explores the release, metabolism, and the effects of binding of ATP and adenosine to their respective receptors in the context of RA, as well as their potential use as biomarkers and therapeutic targets. |
Databáze: | OpenAIRE |
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