Comparison of Luteolytic Potencies of Aminoglutethimide Enantiomers in the Rabbit and Rat*
| Autor: | J. Hourihan, T. Colton, J. M. Strauss, Hilton A. Salhanick, C. Alonso Whipple |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Pharmacology Endocrinology Corpus Luteum In vivo Internal medicine medicine Animals Potency Secretion Progesterone Chemistry Ovary Stereoisomerism Rabbit (nuclear engineering) Aminoglutethimide Rats Luteolytic Agents medicine.anatomical_structure Racemic mixture Biological Assay Female Rabbits Enantiomer Corpus luteum medicine.drug |
| Zdroj: | Endocrinology. 103:1605-1610 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-103-5-1605 |
| Popis: | The luteolytic potency of D- and L-aminoglutethimide (D- and L-AG) was compared in in vivo assays in the rat and rabbit. By assay of plasma progesterone depletion in the rabbit, the potency of L-AG relative to D-AG was 0.21. By the plasma procedure in the rat, the relative potencies of L-AG and of the racemic mixture to D-AG were 0.04 and 0.37, respectively. By the ovarian progesterone depletion method, the L-form had very little activity and the DL-mixture was half as active as the D-isomer. Thus, in both species, almost all of the activity of the racemic mixture results from the content of D-AG. Interpretation of paradoxical data implies that in the rat, L-AG may inhibit liver degradation of progesterone at levels which do not modify secretion from the corpus luteum. |
| Databáze: | OpenAIRE |
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