Impact of Diabetes on Epidemiology, Treatment, and Outcomes of Patients With Heart Failure
| Autor: | Mihai Gheorghiade, Sadiya S. Khan, Diethelm Tschoepe, Wolfram Doehner, Javed Butler, Gregg C. Fonarow, Angelo Avogaro, Stephen J. Greene, Michele Senni, Alessandra Dei Cas, Robert O. Bonow, Robert J. Mentz |
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| Přispěvatelé: | Dei Cas, A, Khan, S, Butler, J, Mentz, R, Bonow, R, Avogaro, A, Tschoepe, D, Doehner, W, Greene, S, Senni, M, Gheorghiade, M, Fonarow, G |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Diabetes mellitu Adrenergic beta-Antagonists Population Angiotensin-Converting Enzyme Inhibitors Heart failure Diabetic cardiomyopathy Fatty Acids Nonesterified Vascular Remodeling Mitochondria Heart Renin-Angiotensin System Internal medicine Diabetes mellitus Epidemiology Diabetes Mellitus medicine Humans In patient Renal Insufficiency Diuretics education education.field_of_study business.industry Myocardium Heart medicine.disease Pathophysiology Autonomic Nervous System Diseases Concomitant Physical therapy Insulin Resistance Cardiology and Cardiovascular Medicine business |
| Popis: | The prevalence of patients with concomitant heart failure (HF) and diabetes mellitus (DM) continues to increase with the general aging of the population. In patients with chronic HF, prevalence of DM is 24% compared with 40% in those hospitalized with worsening HF. Patients with concomitant HF and DM have diverse pathophysiologic, metabolic, and neurohormonal abnormalities that potentially contribute to worse outcomes than those without comorbid DM. In addition, although stable HF outpatients with DM show responses that are similar to those of patients without DM undergoing evidence-based therapies, it is unclear whether hospitalized HF patients with DM will respond similarly to novel investigational therapies. These data support the need to re-evaluate the epidemiology, pathophysiology, and therapy of HF patients with concomitant DM. This paper discusses the role of DM in HF patients and underscores the potential need for the development of targeted therapies. |
| Databáze: | OpenAIRE |
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