Electrophysiologic pattern and prevalence of subclinical peripheral neuropathy in children and adolescents with type I diabetes mellitus in Iran
| Autor: | Robabeh Ghergherechi, Nader-Yousefzadeh Khiabani, Siamak Shiva, Vahideh Toopchizadeh |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Sensory axonal neuropathy Adolescent Neural Conduction lcsh:Medicine 030209 endocrinology & metabolism Neurological examination Iran Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Diabetic Neuropathies Internal medicine Diabetes mellitus Severity of illness medicine Humans 030212 general & internal medicine Child Subclinical infection Type 1 diabetes medicine.diagnostic_test business.industry lcsh:R General Medicine medicine.disease Electrophysiological Phenomena Surgery Cross-Sectional Studies Diabetes Mellitus Type 1 Peripheral neuropathy Asymptomatic Diseases Nerve conduction study Original Article business |
| Zdroj: | Saudi Medical Journal Saudi Medical Journal, Vol 37, Iss 3, Pp 299-303 (2016) |
| ISSN: | 1658-3175 0379-5284 |
| DOI: | 10.15537/smj.2016.3.13625 |
| Popis: | Objectives: To evaluate electrophysiologic pattern of subclinical diabetic peripheral neuropathy (DPN) in children and adolescents with type 1 diabetes mellitus (T1DM) based on nerve conduction study. Methods: In this cross sectional study, 40 children and adolescents (62.5% female with mean age of 12.73 ± 0.43 years) with T1DM for at least 5 years attending the Pediatrics Clinics، Tabriz University of Medical Sciences, Tabriz, Iran, between 2014 and 2015 were recruited. Demographic and laboratory findings were recorded and all patients underwent clinical neurological examination and electrophysiologic studies. Results: According to electrophysiologic studies, DPN was found in 57.5% of patients including early stage of neuropathy (15%), mild sensory axonal neuropathy (25%), mild sensory motor axonal neuropathy (10%), and moderate sensory motor axonal neuropathy (7.5%). Age, duration of diabetes, fasting blood sugar, and glycosylated hemoglobin levels had no significant difference between patients with and without DPN. Reduced deep tendon reflexes were observed in the upper limb (30%) and lower limb (47.5%) of patients, which were both significantly higher in DPN patients (upper limb [ p =0.03] and lower limb [ p =0.04]). The most frequent electrophysiologic findings were unobtainable H-reflex, low amplitude sural, and median sensory responses. Conclusion: Subclinical DPN is a common complication found in children and adolescents with TIDM and peripheral sensory axonal neuropathy is the most frequent type. Nerve conduction study is recommended for early detection of DPN and prevention of its progress. Saudi Med J 2016; Vol. 37 (3): 299-303 doi: 10.15537/smj.2016.3.13625 How to cite this article Toopchizadeh V, Shiva S, Khiabani NY, Ghergherechi R. Electrophysiologic pattern and prevalence of subclinical peripheral neuropathy in children and adolescents with type I diabetes mellitus in Iran. Saudi Med J 2016; 37: 299-303. |
| Databáze: | OpenAIRE |
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