Surveillance of immunity acquired from poliovirus immunization including vaccination with the Sabin strain-derived inactivated vaccine

Autor: Hiroshi Shirasawa, Chiemi Hotta, Tomoko Ogawa
Rok vydání: 2019
Předmět:
Male
Antibodies
Viral
medicine.disease_cause
0302 clinical medicine
Immunology and Allergy
030212 general & internal medicine
Neutralizing antibody
health care economics and organizations
biology
Poliovirus
neutralizing antibody
virus diseases
Poliomyelitis
Vaccination
Child
Preschool
Epidemiological Monitoring
Female
Sabin strains
Sabin strain
Research Paper
education
030231 tropical medicine
Immunology
Immunization
Secondary
behavioral disciplines and activities
complex mixtures
03 medical and health sciences
Immunity
mental disorders
medicine
Humans
seropositive rates
Immunization Schedule
Pharmacology
Immunization Programs
business.industry
Infant
Newborn
Infant
social sciences
inactivated vaccine
biochemical phenomena
metabolism
and nutrition
medicine.disease
Antibodies
Neutralizing
Virology
Poliovirus Vaccine
Inactivated
Immunization
Poliovirus Vaccine
Oral
Inactivated vaccine
biology.protein
bacteria
business
Zdroj: Human Vaccines & Immunotherapeutics
ISSN: 2164-554X
2164-5515
DOI: 10.1080/21645515.2019.1572408
Popis: In Japan, routine immunization for polio using the oral polio vaccine (OPV) was suspended in September 2012; subsequently, an immunization program with inactivated polio vaccines (IPVs), the conventional IPV (cIPV) derived from virulent strains, and IPV derived from Sabin strains (sIPV), was introduced. However, the immunity induced by sIPV is not well characterized. This study assessed and compared neutralizing antibodies produced against poliovirus in cases who received doses of OPV or IPV. Serum samples (n = 1186) were collected yearly between 2013 and 2016 as part of the National Epidemiological Surveillance of Vaccine–Preventable Disease. The neutralizing antibody titers for Sabin strain types 1, 2, and 3 in 224 children, aged between 0 and 90 months, were assessed. Seropositive rates after vaccination with OPV or IPV were more than 90%. Neutralizing antibody titers for Sabin type 1 after vaccination with IPV were lower than those with OPV, while those for Sabin types 2 and 3 after vaccination with IPV were significantly higher than those with OPV. Analyses of antibody titer dynamics revealed that the decay of antibody titers for Sabin types 1, 2, and 3 in cases vaccinated with IPV was steeper than those with OPV. Thus, our study showed that although IPV induced a sufficient level of neutralizing antibody, the immunity induced by IPV was not maintained as long as that by OPV. Our study suggested that a long-term survey should be conducted for polio vaccination using IPV and that it might be necessary to consider booster vaccination for IPVs.
Databáze: OpenAIRE
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