Comparison of blood lead concentrations in patients with acute ischemic stroke and healthy subjects
| Autor: | Abolfazl Talebi, Alireza Amirabadizadeh, Roland J. Lamarine, Omid Mehrpour, Emad Yeganeh Khorasani, Amin Baharshahi, Samaneh Nakhaee, Ali Rajabpour-Sanati, Seyed Mohammad Mousavi-Mirzaei, Mahsa Mehrpour |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Incidence (epidemiology) Population Healthy subjects 010501 environmental sciences medicine.disease 01 natural sciences Biochemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Internal medicine Toxicity medicine Molecular Medicine In patient Risk factor Lead (electronics) business education Stroke 030217 neurology & neurosurgery 0105 earth and related environmental sciences |
| Zdroj: | Journal of Trace Elements in Medicine and Biology. 61:126532 |
| ISSN: | 0946-672X |
| DOI: | 10.1016/j.jtemb.2020.126532 |
| Popis: | Stroke is the main cause of mortality and long-term disability in the general population. With the increased application of metals in industries and human environment, lead has become a health hazard. In this study, we aimed to evaluate the relationship between the blood concentration of lead and the incidence of acute stroke.We performed this study during 2016-17 at Vali-e-Asr Hospital in Birjand, Iran, among 80 ischemic stroke patients visiting the hospital and 80 healthy gender- and age-matched controls. Blood lead concentration (BLC) was measured using graphite furnace atomic absorption spectrometry.BLC medians in the case and control groups were 20.65 [5.37-34.87] μg/dL and 2.65 [1.75-13.85] μg/dL, respectively (p0.05). The case group had significantly lower mean levels of HDL and phosphors, whereas the mean levels of white blood cells and uric acid were higher in this group. After adjusting for lipid profile and fasting blood sugar, multiple logistic regression indicated that the serum levels of uric acid and BLC were significant for predicting ischemic stroke. It is estimated that the odds ratio of ischemic stroke increases by 1.04 per 1 μg/dl increase in BLC.This study showed that lead can be a risk factor for ischemic stroke. Since it does not have any beneficial effects on the health of individuals, screening serum concentrations of lead can be considered as a preventive strategy for those at risk of stroke. |
| Databáze: | OpenAIRE |
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