Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period
| Autor: | Martin Karamanliev, Assia Konsoulova, Angel Yordanov, Strahil Strashilov, Mariela Vasileva-Slaveva, Latchezar Tantchev |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
mucoepidermoid cervical carcinoma survival rate medicine.medical_specialty Adenosquamous carcinoma adenosquamous carcinoma Uterine Cervical Neoplasms Stage I Cervical Cancer Gynecologic oncology Gastroenterology Article Mucoepidermoid carcinoma Internal medicine medicine Humans Bulgaria Survival rate Cervix Neoplasm Staging Retrospective Studies Cervical cancer lcsh:R5-920 business.industry General Medicine Middle Aged lymph node involvment medicine.disease Prognosis Primary tumor stomatognathic diseases medicine.anatomical_structure Carcinoma Mucoepidermoid Female Lymph Nodes business lcsh:Medicine (General) |
| Zdroj: | Medicina; Volume 56; Issue 1; Pages: 37 Medicina Volume 56 Issue 1 Medicina, Vol 56, Iss 1, p 37 (2020) |
| ISSN: | 1648-9144 |
| DOI: | 10.3390/medicina56010037 |
| Popis: | Background and objectives: Adenosquamous cancer of the uterine cervix is a rare type of cervical cancer with both malignant squamous and glandular components. A very rare subtype is mucoepidermoid carcinoma (MEC), which was first described as a salivary gland tumor. It has been described as having the appearance of a squamous cell carcinoma without glandular formation and contains intracellular mucin. The postoperative evolution of this tumor and the potentially poorer prognosis may indicate an intensification of the follow-up. The objective of our study was to analyze the frequency of mucoepidermoid carcinoma in hospitalized women with cervical cancer, clinical characteristics and prognosis. Material and Methods: A retrospective study of all cases of mucoepidermoid carcinoma of the cervix at Department of Gynecologic Oncology,University Hospital&mdash Pleven, Pleven Bulgaria between 1 January 2007 and 31 December 2016 was performed. All patients were followed-up till December 2019. We analyzed certain clinical characteristics of the patients calculated the frequency of mucoepidermoid carcinoma of the cervix from all patients with stage I cervical cancer and looked at the overall survival rate, correlation between overall survival, lymph node status and the size of the tumor. Results: The frequency of MEC was 1.12% of all patients with stage I cervical cancer in this study. The median age of the patients with MEC was 46.7 years (range 38&ndash 62). Four patients (57.1%) were staged as FIGO IB1, and three patients (42.8%) were FIGO IB2. The size of the primary tumor was < 2 cm in 2 patients (28.57%), 2&ndash 4 cm in 2 patients (28.57%) and > 4 cm in 3 patients (42.8%). Metastatic lymph nodes were found in two patients (28.57%), and nonmetastatic lymph nodes were found in five patients (71.43%). There were two (28.57%) disease-related deaths during the study period. The five-year observed survival in the MEC group was 85.7% and in the other subtypes of adenosquamous cancer group was 78.3%. Conclusions: MEC of the uterine cervix is a rare entity diagnosis. As a mucin-producing tumor, it is frequently regarded as a subtype with worse clinical behavior and patients&rsquo outcomes. Nevertheless, our data did not confirm this prognosis. New molecular markers and better stratification are needed for better selection of patients with CC, which may benefit more from additional treatment and new target therapies. |
| Databáze: | OpenAIRE |
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