The formation of platelet–leukocyte aggregates varies during the menstrual cycle

Autor:	Christiane Rosin, Peter Quehenberger, Stephan Lehr, Simon Panzer, Markus Brunner
Rok vydání:	2006
Předmět:	Adult Blood Platelets medicine.medical_specialty Platelet Aggregation P-selectin Fibrinogen receptor medicine.drug_class media_common.quotation_subject Biology Reference Values Internal medicine Thrombin receptor Cell Adhesion Leukocytes medicine Humans Platelet Protein Phosphatase 2 Receptor Ovulation Menstrual Cycle Menstrual cycle media_common Platelet Count Dual Specificity Phosphatase 2 Fibrinogen Estrogens Hematology General Medicine Flow Cytometry Platelet Activation P-Selectin Receptors Fibrinogen Endocrinology Estrogen Female Protein Tyrosine Phosphatases
Zdroj:	Platelets. 17:61-66
ISSN:	1369-1635 0953-7104
DOI:	10.1080/09537100500227021
Popis:	Platelet-leukocyte aggregates are considered to play a significant role in blood coagulation and inflammatory processes. We hypothesized that hormonal changes during the menstrual cycle affect the formation of heterotypic aggregates and therefore may constitute cycle-dependent variations of the susceptibility for thromboembolic events and inflammatory disease. We therefore measured platelet-leukocyte interaction by the determination of platelet-leukocyte aggregates (PLA), platelet P-Selectin expression, and platelet fibrinogen receptor activation by PAC-1 binding in 20 healthy women during their menstrual cycle by flow cytometry. The number of platelet-granulocyte aggregates (PGA) and platelet-monocyte aggregates (PMA) was higher at ovulation compared to any other time-point of the menstrual cycle (p = 0.005, p = 0.022, respectively). Likewise, P-Selectin expression peaked on day 14 (p = 0.040). The course of PLA formation during the menstrual cycle followed the course of estrogen levels, strongly suggesting direct effects of estrogen on platelet-leukocyte interaction. The susceptibility to form platelet-leukocyte aggregates that are inducible in vitro by a suboptimal concentration of thrombin receptor activating peptide-6 decreased slightly during the transition from day 1 to 14 (p = 0.040). These data indicate that platelet function varies during particular phases of the normal menstrual cycle.
Databáze:	OpenAIRE
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