Isoniazid-induced hepatotoxicity in children with latent tuberculosis infection
| Autor: | Demet Can, Nuri Bayram, Hurşit Apa, Hüseyin Aktürk, İlker Devrim, A. Kara, Fatma Devrim |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Antitubercular Agents Gastroenterology World health Age and gender Latent Tuberculosis Internal medicine medicine Isoniazid Humans In patient Child Latent tuberculosis business.industry Incidence (epidemiology) Incidence Infant Newborn Infant bacterial infections and mycoses medicine.disease Median time Child Preschool Pediatrics Perinatology and Child Health Toxicity Female Chemical and Drug Induced Liver Injury business medicine.drug |
| Zdroj: | Minerva pediatrics. 73(2) |
| ISSN: | 2724-5780 |
| Popis: | Objectives We aimed to determine overall incidence of severe and mild isoniazid (INH) hepatotoxicity and outcome of hepatotoxicity in children who were receiving INH for latent tuberculosis. Methods Patients who had received isoniazid for treatment of latent tuberculosis were included in the study. Hepatotoxicity was classified according to the World Health Organization Toxicity Classification Standards. Results Among 1038 patients, overall hepatotoxicity was observed in 23 patients (2.2 %), while 5 patients (0.48 %) had moderate - severe hepatotoxicity; while other 18 patients had grade I - II hepatotoxicity (1.73%). Age and gender did not appear to be risk factors for hepatotoxicity. The median time for therapy rechallenge in patients with grade III - IV hepatotoxicity was 21 days (ranging from 14 to 25 days). Conclusions Isoniazid hepatotoxicity is lower and generally reversible after cessation of INH in children. The grade of hepatotoxicity affects the duration for recovery of hepatotoxicity and restarting of INH therapy. |
| Databáze: | OpenAIRE |
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