Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis
| Autor: | Jong-Won Kim, Seung-mi Hwang, Chung-berm Park, Hee-Won Moon, Ye-Eun Lee, Daram Yang, Hyo-Bin Oh, Bumseok Kim, Hyuneui Jeong |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Inflammation Pharmacology Jinan Red Ginseng Biochemistry Genetics and Molecular Biology (miscellaneous) Palmitic acid 03 medical and health sciences chemistry.chemical_compound Ginseng Licorice Mice 0302 clinical medicine Oral administration Fibrosis medicine Nonalcoholic steatohepatitis business.industry Botany AMPK Lipid metabolism medicine.disease 030104 developmental biology Complementary and alternative medicine chemistry QK1-989 030220 oncology & carcinogenesis Lipogenesis medicine.symptom business Biotechnology Research Article |
| Zdroj: | Journal of Ginseng Research Journal of Ginseng Research, Vol 46, Iss 1, Pp 126-137 (2022) |
| ISSN: | 1226-8453 |
| Popis: | Background Nonalcoholic steatohepatitis (NASH) is one of the main chronic liver diseases. NASH is identified by lipid accumulation, inflammation, and fibrosis. Jinan Red Ginseng (JRG) and licorice have been widely used because of their anti-inflammatory and hepatoprotective effects. Hence, this study assessed JRG and licorice extract mixtures' effects on NASH progression. Methods Palmitic acid (PA) and the western diet (WD) plus, high glucose-fructose water were used to induce in vitro and in vivo NASH. Mice were orally administered with JRG-single (JRG-S) and JRG-mixtures (JRG-M; JRG-S + licorice) at 0, 50, 100, 200 or 400 mg/kg/day once a day during the last half-period of diet feeding. Results JRG-S and JRG-M reduced NASH-related pathologies in WD-fed mice. JRG-S and JRG-M consistently decreased the mRNA level of genes related with inflammation, fibrosis, and lipid metabolism. The treatment of JRG-S and JRG-M also diminished the SREBP-1c protein levels and the p-AMPK/AMPK ratio. The FAS protein levels were decreased by JRG-M treatment both in vivo and in vitro but not JRG-S. Conclusion JRG-M effectively reduced lipogenesis by modulating AMPK downstream signaling. Our findings suggest that this mixture can be used as a prophylactic or therapeutic alternative for the remedy of NASH. Graphical abstract Image 1 |
| Databáze: | OpenAIRE |
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