Roles of Insulin, Age, and Asymmetric Dimethylarginine on Nitric Oxide Synthesis In Vivo
Autor: | Monica Vedovato, Carlo Artusi, Lucia Puricelli, Renato Millioni, Paolo Tessari, Monica Vettore, Mario Plebani, Diego Cecchet |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty hypertension Endocrinology Diabetes and Metabolism medicine.medical_treatment Hypercholesterolemia Blood Pressure Arginine Nitric Oxide Nitric oxide chemistry.chemical_compound Insulin resistance Internal medicine Diabetes mellitus Internal Medicine medicine Hyperinsulinemia insulin sensitivity Humans Insulin NOx Aged nitric oxide ageing Original Research Online Letters to the Editor Chemistry Age Factors Type 2 Diabetes Mellitus Middle Aged medicine.disease Endocrinology Metabolism Diabetes Mellitus Type 2 Insulin Resistance Asymmetric dimethylarginine |
Zdroj: | Diabetes |
ISSN: | 1939-327X 0012-1797 |
Popis: | We tested the effects of insulin on production of nitrous oxide (NO)-related substances (nitrites and nitrates [NOx]) after 15N-arginine intravenous infusion and on asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) concentrations in conditions reportedly associated with altered NO availability, i.e., aging, hypertension, hypercholesterolemia, and type 2 diabetes mellitus (T2DM). A total of 26 male subjects (age 23–71 years, BMI 23–33 kg/m2), some of whom were affected by mixed pathologic features, were enrolled. NOx fractional synthesis rate (FSR) was lower in elderly (P < 0.015) and T2DM subjects (P < 0.03) than in matched control subjects. Hyperinsulinemia generally increased both NOx FSR and absolute synthesis rate (ASR) and reduced NOx, ADMA, and SDMA concentrations. Insulin sensitivity was impaired only in T2DM. With use of simple linear regression analysis across all subjects, age was inversely correlated with both NOx FSR (R2 = 0.23, P < 0.015) and ASR (R2 = 0.21, P < 0.02). NOx FSR inversely correlated with both ADMA and SDMA. With use of multiple regression analysis and various models, NOx FSR remained inversely associated with age and ADMA, whereas ASR was inversely associated with age and diabetes. No association with insulin sensitivity was found. We conclude that whole-body NOx production is decreased in aging and T2DM. Age, ADMA concentration, and T2DM, but not insulin resistance, appear as negative regulators of whole-body NOx production. |
Databáze: | OpenAIRE |
Externí odkaz: |