Evidence of a direct action of triiodothyronine (T3) on the cell membrane of GH3 cells: an electrophysiological approach
| Autor: | J. M. Israel, J. S. du Pont |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Action Potentials Biology Cell Line Membrane Potentials Cell membrane Cellular and Molecular Neuroscience Internal medicine medicine Animals Pituitary Neoplasms Molecular Biology Pharmacology Membrane potential Triiodothyronine Cell Membrane Electric Conductivity Biological activity Cell Biology Hyperpolarization (biology) Rats Cell biology Electrophysiology Membrane Endocrinology medicine.anatomical_structure Cell culture Molecular Medicine |
| Zdroj: | Experientia. 43:596-598 |
| ISSN: | 1420-9071 0014-4754 |
| DOI: | 10.1007/bf02126342 |
| Popis: | Electrophysiological experiments demonstrate that triiodothyronine (T3) exerts a direct effect on the membrane of a strain of cultured rat pituitary tumor cells, GH3/B6. These cells respond to pressure application of T3 (2-5 nl, concentration 1 X 10(-10) M) with an increase in the membrane resistance (Rm) and a hyperpolarization. Spontaneously firing cells become silent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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