Statins use and COVID-19 outcomes in hospitalized patients

Autor: Petros C. Karakousis, Oluwatobi Lasisi, Richard D. Nudotor, Samuel K. Ayeh, Emmanuella L. Salia, Ngozi Osuji, Enoch J. Abbey, Samiha Khan, Banda A. A. Khalifa, Albert D. Osei, Modupe O. Oduwole, Hasiya E. Yusuf, Vignesh Chidambaram, Esosa Nosakhare
Rok vydání: 2021
Předmět:
Male
Viral Diseases
Epidemiology
Physiology
medicine.medical_treatment
Logistic regression
Body Mass Index
Medical Conditions
Endocrinology
Medicine and Health Sciences
Multidisciplinary
Mortality rate
Drugs
Middle Aged
Hospitals
Infectious Diseases
Physiological Parameters
Nephrology
Medicine
Female
Research Article
Adult
medicine.medical_specialty
Statin
Death Rates
Endocrine Disorders
medicine.drug_class
Science
Population Metrics
Internal medicine
Diabetes mellitus
Medical Dialysis
Diabetes Mellitus
medicine
Humans
Aged
Retrospective Studies
Pharmacology
Mechanical ventilation
Population Biology
business.industry
Body Weight
Statins
Biology and Life Sciences
Covid 19
Retrospective cohort study
medicine.disease
COVID-19 Drug Treatment
Health Care
Health Care Facilities
Medical Risk Factors
Metabolic Disorders
Propensity score matching
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Body mass index
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0256899 (2021)
ISSN: 1932-6203
Popis: BackgroundThere is an urgent need for novel therapeutic strategies for reversing COVID-19-related lung inflammation. Recent evidence has demonstrated that the cholesterol-lowering agents, statins, are associated with reduced mortality in patients with various respiratory infections. We sought to investigate the relationship between statin use and COVID-19 disease severity in hospitalized patients.MethodsA retrospective analysis of COVID-19 patients admitted to the Johns Hopkins Medical Institutions between March 1, 2020 and June 30, 2020 was performed. The outcomes of interest were mortality and severe COVID-19 infection, as defined by prolonged hospital stay (≥ 7 days) and/ or invasive mechanical ventilation. Logistic regression, Cox proportional hazards regression and propensity score matching were used to obtain both univariable and multivariable associations between covariates and outcomes in addition to the average treatment effect of statin use.ResultsOf the 4,447 patients who met our inclusion criteria, 594 (13.4%) patients were exposed to statins on admission, of which 340 (57.2%) were male. The mean age was higher in statin users compared to non-users [64.9 ± 13.4 vs. 45.5 ± 16.6 years, p ConclusionStatin use was not associated with altered mortality, but with an 18% increased risk of severe COVID-19 infection.
Databáze: OpenAIRE
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