Serum hepcidin concentrations in relation to iron status in children with type 1 diabetes
| Autor: | Coby M. Laarakkers, M. Claire Woltering, Mirjam Vreugdenhil, Boudewijn Bakker, Marjolijn D. Akkermans, Dick Mul, Rachel P. L. van Swelm, Daniëlle C M van der Kaay, Euphemia C. A. M. Houdijk, Frank Brus, Martine C. de Vries, Agnes Clement-de Boers, Johannes B. van Goudoever |
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| Přispěvatelé: | Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D) |
| Rok vydání: | 2021 |
| Předmět: |
Male
endocrine system medicine.medical_specialty endocrine system diseases Adolescent type 1 diabetes Iron Inflammation 03 medical and health sciences 0302 clinical medicine iron deficiency Anti-Infective Agents Hepcidins immune system diseases Hepcidin Internal medicine Medicine Humans iron status Children Type 1 diabetes biology Anemia Iron-Deficiency business.industry nutritional and metabolic diseases Hematology Iron deficiency medicine.disease Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] Endocrinology Cross-Sectional Studies Diabetes Mellitus Type 1 Oncology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health biology.protein Female Iron status hepcidin medicine.symptom business 030215 immunology |
| Zdroj: | Pediatric Hematology and Oncology, 38, 108-123 Pediatric hematology and oncology, 38(2), 108-123. Informa Healthcare Pediatric Hematology and Oncology, 38, 2, pp. 108-123 |
| ISSN: | 0888-0018 |
| Popis: | Chronic low-grade inflammation in type 1 diabetes (T1D) might increase hepcidin synthesis, possibly resulting in functional iron deficiency (FID). We hypothesized that in T1D children with FID, hepcidin concentrations are increased compared to those with normal iron status and those with absolute iron deficiency (AID). We evaluated hepcidin concentrations in T1D children in relation to iron status, and investigated whether hepcidin is useful in assessing FID. A cross-sectional study was conducted. FID was defined as elevated zinc protoporphyrin/heme ratio and/or red blood cell distribution width, and AID as low serum ferritin concentration. Post-hoc analyses with different definitions of FID were performed, using transferrin saturation and reticulocyte hemoglobin content. Serum hepcidin concentrations were measured using mass-spectrometry. The IRODIAB-study is registered at www.trialregister.nl (NTR4642). This study included 215 T1D children with a median age of 13.7 years (Q 1–Q 3: 10.1–16.3). The median (Q 1–Q 3) hepcidin concentration in patients with normal iron status was 1.8 nmol/l (0.9–3.3), in AID-patients, 0.4 nmol/l (0.4–0.4) and in FID-patients, 1.6 nmol/l (0.7–3.5). Hepcidin concentrations in FID-patients were significantly higher than in AID-patients (p < 0.001). Irrespective of FID-definition used, hepcidin concentrations did not differ between FID-patients and patients with normal iron status. This might be explained by the influence of various factors on hepcidin concentrations, and/or by differences in response of iron parameters over time. Single hepcidin measurements do not seem useful in assessing FID in T1D children. Multiple hepcidin measurements over time in future studies, however, might prove to be more useful in assessing FID in children with T1D. |
| Databáze: | OpenAIRE |
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