When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis
| Autor: | Teny M. John, Ceena N. Jacob, Dimitrios P. Kontoyiannis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
2019-20 coronavirus outbreak Pediatrics medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Plant Science Review Aspergillosis mucormycosis 03 medical and health sciences 0302 clinical medicine Diabetes mellitus medicine In patient 030212 general & internal medicine lcsh:QH301-705.5 Ecology Evolution Behavior and Systematics 0303 health sciences 030306 microbiology business.industry Mucormycosis COVID-19 medicine.disease lcsh:Biology (General) diabetes mellitus Presentation (obstetrics) business |
| Zdroj: | Journal of Fungi Journal of Fungi, Vol 7, Iss 298, p 298 (2021) |
| ISSN: | 2309-608X |
| Popis: | Mucormycosis (MCR) has been increasingly described in patients with coronavirus disease 2019 (COVID-19) but the epidemiological factors, presentation, diagnostic certainty, and outcome of such patients are not well described. We review the published COVID-19-associated mucormycosis (CAMCR) cases (total 41) to identify risk factors, clinical features, and outcomes. CAMCR was typically seen in patients with diabetes mellitus (DM) (94%) especially the ones with poorly controlled DM (67%) and severe or critical COVID-19 (95%). Its presentation was typical of MCR seen in diabetic patients (mostly rhino-orbital and rhino-orbital-cerebral presentation). In sharp contrast to reported COVID-associated aspergillosis (CAPA) cases, nearly all CAMCR infections were proven (93%). Treating physicians should have a high suspicion for CAMCR in patients with uncontrolled diabetes mellitus and severe COVID-19 presenting with rhino-orbital or rhino-cerebral syndromes. CAMR is the convergence of two storms, one of DM and the other of COVID-19. |
| Databáze: | OpenAIRE |
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