Framingham Stroke Risk Profile is related to cerebral small vessel disease progression and lower cognitive performance in patients with hypertension
| Autor: | Robert J. van Oostenbrugge, Peter W. de Leeuw, Marjolein Huijts, Abraham A. Kroon, Renske Uiterwijk, Julie Staals |
|---|---|
| Přispěvatelé: | RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Promovendi MHN, Klinische Neurowetenschappen, MUMC+: MA Niet Med Staf Neurologie (9), RS: CARIM - R3.03 - Cerebral small vessel disease, MUMC+: MA Med Staf Spec Neurologie (9), MUMC+: MA Niet Med Staf Psychologie (9), Interne Geneeskunde, RS: CARIM - R3.02 - Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), MUMC+: MA Neurologie (3) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
cognition MICROBLEEDS Endocrinology Diabetes and Metabolism Neuropsychological Tests 030204 cardiovascular system & hematology Essential hypertension 0302 clinical medicine Risk Factors Framingham stroke risk profile Longitudinal Studies Neuropsychological assessment Stroke POPULATION Netherlands education.field_of_study Framingham Risk Score medicine.diagnostic_test cerebral small vessel disease DEMENTIA Brain Middle Aged WHITE-MATTER LESIONS DEPRESSION Magnetic Resonance Imaging 3. Good health PREVALENCE HYPERINTENSITIES Research Design Cardiovascular Effects of Hypertension Disease Progression Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine Adult medicine.medical_specialty hypertension Population Brain damage Risk Assessment 03 medical and health sciences Internal medicine Internal Medicine medicine Humans Dementia SILENT BRAIN INFARCTS COHORT education DECLINE business.industry medicine.disease Hyperintensity Cerebral Small Vessel Diseases business 030217 neurology & neurosurgery |
| Zdroj: | J Clin Hypertens (Greenwich) Journal of Clinical Hypertension, 20(2), 240-245. Wiley |
| ISSN: | 1524-6175 |
| Popis: | The Framingham Stroke Risk Profile (FSRP) was developed to predict clinical stroke. We investigated if FSRP is associated with more "silent" effects of cerebrovascular disease, namely progression of cerebral small vessel disease (cSVD)-related brain damage and cognitive performance in hypertensive patients. Ninety patients with essential hypertension underwent a brain MRI scan and FSRP assessment at baseline, and a second brain MRI scan and neuropsychological assessment at 9-year follow-up. We visually rated progression of cSVD-related MRI markers. FSRP was associated with progressive periventricular white matter hyperintensities (P = .017) and new microbleeds (P = .031), but not after correction for the FSRP age component. FSRP was associated with lower overall cognitive performance (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|