X-linked agammaglobulinemia - gene cloning and future prospects
| Autor: | Roland J. Levinsky, Steve Hinshelwood, Christine Kinnon, Ruth C. Lovering |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
X Chromosome
Genetic Linkage Immunology X-linked agammaglobulinemia Biology Homology (biology) Mice Agammaglobulinemia immune system diseases hemic and lymphatic diseases Agammaglobulinaemia Tyrosine Kinase medicine Animals Humans Bruton's tyrosine kinase Cloning Molecular Gene X chromosome Immunodeficiency Genetics B-Lymphocytes Gene rearrangement Protein-Tyrosine Kinases medicine.disease Disease Models Animal Mice Inbred CBA biology.protein Tyrosine kinase Forecasting |
| Zdroj: | Immunology Today. 14:554-558 |
| ISSN: | 0167-5699 |
| DOI: | 10.1016/0167-5699(93)90187-p |
| Popis: | The btk gene has recently been identified as the causative gene in X-linked agammaglobulinemia (XLA). This has opened up many new possibilities for the treatment of this B-cell immunodeficiency. Christine Kinnon and colleagues review the high degree of sequence of homology of btk to the non-receptor tyrosine kinases and speculate on putative roles for this gene in B-cell development. |
| Databáze: | OpenAIRE |
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