Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats
| Autor: | Shaik Sameena Fatima, B Ramesh, Sirasanagandla Swapna, Vinay Kumar Kondeti, Ramesh B. Kasetti, Ethamakula Guravaiah Tiruvenkata Kumar, Maddirala Dilip Rajasekhar, Chippada Appa Rao |
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| Rok vydání: | 2010 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Syzygium Fractionation Chemical Fractionation Toxicology Streptozocin Diabetes Mellitus Experimental Glibenclamide chemistry.chemical_compound Liver Function Tests Diabetes mellitus Internal medicine Glyburide medicine Animals Hypoglycemic Agents Insulin Aspartate Aminotransferases Rats Wistar Hypolipidemic Agents Glycated Hemoglobin Creatinine Plant Extracts Methanol Water Alanine Transaminase Biological activity General Medicine Alkaline Phosphatase medicine.disease Streptozotocin Lipids Rats Endocrinology chemistry Sephadex Seeds Glycated hemoglobin Food Science medicine.drug |
| Zdroj: | Food and Chemical Toxicology. 48:1078-1084 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2010.01.029 |
| Popis: | The present study was taken up to identify potent antihyperglycemic fraction from the aqueous extract of Syzygium alternifolium (SA) seeds, using bioassay guided fractionation. The isolated fraction C at a dose of 50 mg/kg.b.w produced the maximum fall of 83% in the blood glucose level in the diabetic rats after 6 h of the treatment. The administration of fraction C (50 mg/kg.b.w) once daily for 30 days in STZ diabetic rats resulted in a significant decrease in blood glucose, glycosylated haemoglobin with a significant rise in plasma insulin level. Further fraction C showed antihyperlipidemic activity as evidenced by significant decrease in serum TC, TG, LDL-C, VLDL-C levels coupled together with elevation of HDL-C level in diabetic rats. A significant decrease in the activities of SGOT, SGPT, ALP and decreased levels of serum urea and creatinine in diabetic treated rats when compared to diabetic untreated rats, indicate the protective role against liver and kidney damage and non-toxic property of the fraction C. A comparison was made between the action of fraction C and antidiabetic drug glibenclamide (20 mg/kg.b.w). The effect of fraction C was more prominent when compared to that of glibenclamide. |
| Databáze: | OpenAIRE |
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